Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia

Episode 152

September 29, 2025

152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia

️ Episode 152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia In this episode of PaperCast Base by Base, we explore a validated single‑well multiplex...

Play

00:16:53

151: EQA of ctDNA Mutation Testing Across the COIN Consortium

Episode 151

September 28, 2025

151: EQA of ctDNA Mutation Testing Across the COIN Consortium

️ Episode 151: EQA of ctDNA Mutation Testing Across the COIN Consortium In this episode of PaperCast Base by Base, we explore how 16...

Play

00:16:21

150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck

Episode 150

September 27, 2025

150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck

️ Episode 150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck In this episode of PaperCast Base by Base, we explore a Nature Communications...

Play

00:17:52

149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck

Episode 149

September 26, 2025

149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck

️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how patrilineal social structures...

Play

00:15:04

148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

Episode 148

September 25, 2025

148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

️ Episode 148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants In this episode of PaperCast Base by Base,...

Play

00:14:44

147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants

Episode 147

September 24, 2025

147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants

️ Episode 147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants In this episode of PaperCast Base by Base, we explore...

Play

00:15:37

Next