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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Episode 1

November 14, 2025

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells In this episode of PaperCast Base by Base, we explore how physical...

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00:15:47

197: Somatic Mutation and Selection at Population Scale

Episode 197

November 13, 2025

197: Somatic Mutation and Selection at Population Scale

️ Episode 197: Somatic Mutation and Selection at Population Scale In this episode of PaperCast Base by Base, we explore how ultra-accurate NanoSeq duplex...

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00:15:11

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Episode 196

November 12, 2025

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

️ Episode 196: Impact of Chromatin Accessibility QTLs Across Immune Contexts In this episode of PaperCast Base by Base, we explore how single-cell chromatin...

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00:16:37

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Episode 195

November 11, 2025

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

️ Episode 195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore how a subset of...

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00:18:22

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

Episode 194

November 10, 2025

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we...

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00:14:29

193: SARM1, DNA, and the Death Signal

Episode 193

November 09, 2025

193: SARM1, DNA, and the Death Signal

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts...

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00:15:00

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