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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

Episode 174

October 21, 2025

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore...

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00:16:40

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

Episode 173

October 20, 2025

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS...

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00:20:12

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

Episode 172

October 19, 2025

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we...

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00:19:44

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Episode 171

October 18, 2025

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? In this episode of PaperCast Base by Base, we explore a...

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00:16:14

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Episode 170

October 17, 2025

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

️ Episode 170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans In this episode of PaperCast Base by Base, we explore how maternal...

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00:17:03

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Episode 169

October 16, 2025

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance In this episode of PaperCast Base by Base,...

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00:21:13