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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms

Episode 82

July 21, 2025

️ 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms

️ Episode 82: JAK2 Inhibition Drives RAS Pathway Mutant Clonal Selection in Myeloproliferative Neoplasms In this episode of PaperCast Base by Base, we explore...

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00:19:07

️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

Episode 81

July 20, 2025

️ 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort

️ Episode 81: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore...

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00:21:10

️ 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery

Episode 80

July 19, 2025

️ 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery

️ Episode 80: Genomic Forecasting of Postoperative Outcomes in Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore the use...

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00:16:15

️ 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation

Episode 79

July 18, 2025

️ 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation

️ Episode 79: Cross-Population GWAS and Proteomic Insights in Atrial Fibrillation In this episode of PaperCast Base by Base, we explore a cross-population genome-wide...

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00:17:17

️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer

Episode 78

July 17, 2025

️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer

️ Episode 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer In this episode of PaperCast Base by Base, we explore the discovery...

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00:14:53

️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity

Episode 77

July 16, 2025

️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity

️ Episode 77: Range Extender: Unlocking Long-Distance Enhancer Activity In this episode of PaperCast Base by Base, we explore the discovery and functional characterization...

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00:16:31