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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

Episode 192

November 08, 2025

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin...

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00:14:24

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

Episode 191

November 07, 2025

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...

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00:19:17

190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes

Episode 190

November 06, 2025

190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes

️ Episode 190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes In this episode of PaperCast Base by Base, we explore how...

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00:15:43

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

Episode 189

November 05, 2025

189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how...

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00:14:22

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

Episode 188

November 04, 2025

188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis

️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry...

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00:16:51

187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors

Episode 187

November 03, 2025

187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors

️ Episode 187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors In this episode of PaperCast Base by Base, we explore a phase I...

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00:16:13