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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

140: Landscapes of missense variant impact for human superoxide dismutase 1

Episode 140

September 17, 2025

140: Landscapes of missense variant impact for human superoxide dismutase 1

️ Episode 140: Landscapes of missense variant impact for human superoxide dismutase 1 In this episode of PaperCast Base by Base, we explore a...

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00:20:18

139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data

Episode 139

September 16, 2025

139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data

️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data In this episode of PaperCast Base...

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00:14:03

138: Social exposome and brain health outcomes of dementia across Latin America

Episode 138

September 15, 2025

138: Social exposome and brain health outcomes of dementia across Latin America

️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America In this episode of PaperCast Base by Base, we explore...

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00:19:43

137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

Episode 137

September 14, 2025

137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views

️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views In this episode of PaperCast Base by Base, we explore how a sweeping expansion...

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00:25:11

136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance

Episode 136

September 13, 2025

136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance

️ Episode 136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance In this episode of PaperCast Base by Base, we explore...

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00:14:48

135: Global impact of micronutrients in modern human evolution

Episode 135

September 12, 2025

135: Global impact of micronutrients in modern human evolution

️ Episode 135: Global impact of micronutrients in modern human evolution In this episode of PaperCast Base by Base, we explore how dietary micronutrients...

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00:14:26