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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer

Episode 94

August 02, 2025

️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer

️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integrated DNA methylation,...

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00:20:29

️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13

Episode 93

August 01, 2025

️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13

️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 In this episode of PaperCast Base by Base, we explore how...

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00:19:01

️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration

Episode 92

July 31, 2025

️ 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration

️ Episode 92: Genetic Loss of CFHR5 Function Protects Against Age-Related Macular Degeneration In this episode of PaperCast Base by Base, we explore a...

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00:16:49

️ 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins

Episode 91

July 30, 2025

️ 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins

️ Episode 91: Genome-wide Association of Plasma N-Glycome Reveals Links to Liver Disease and Anti-Inflammatory Proteins In this episode of PaperCast Base by Base,...

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00:17:42

️ 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition

Episode 90

July 29, 2025

️ 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition

️ Episode 90: Variable and Interactive Effects of Sex, APOE ε4 and TREM2 on Tau Deposition In this episode of PaperCast Base by Base,...

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00:15:57

️ 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification

Episode 89

July 28, 2025

️ 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification

️ Episode 89: Decoding the Genetics of Smell: Sex-Specific Variants in Olfactory Identification In this episode of PaperCast Base by Base, we explore how...

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00:20:28