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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

Episode 58

June 28, 2025

️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

️ Episode 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity In this episode of Base by Base, we explore...

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00:22:04

️ 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

Episode 57

June 27, 2025

️ 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

️ Episode 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability In this episode of Base by Base, we...

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00:19:40

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

Episode 56

June 26, 2025

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis In this episode of Base by Base, we examine...

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00:16:01

️ 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin

Episode 55

June 25, 2025

️ 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin

️ Episode 55: Denisovan DNA in Dental Calculus — Linking Morphology and Genetics in a 146,000-Year-Old Hominin In this episode of Base by Base,...

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00:14:34

️ 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease

Episode 54

June 24, 2025

️ 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease

️ Episode 54: Temporal Immune Landscapes — A Multi-Omic Lens on COVID-19 in End-Stage Kidney Disease In this new Base by Base episode we...

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00:18:50

️ 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations

Episode 53

June 23, 2025

️ 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations

️ Episode 53: Weighing the Evidence — A Systematic Review of Polygenic Risk Score Economic Evaluations In this episode of Base by Base, we...

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00:17:13

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