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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck

Episode 150

September 27, 2025

150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck

️ Episode 150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck In this episode of PaperCast Base by Base, we explore a Nature Communications...

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00:17:52

149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck

Episode 149

September 26, 2025

149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck

️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how patrilineal social structures...

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00:15:04

148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

Episode 148

September 25, 2025

148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants

️ Episode 148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants In this episode of PaperCast Base by Base,...

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00:14:44

147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants

Episode 147

September 24, 2025

147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants

️ Episode 147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants In this episode of PaperCast Base by Base, we explore...

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00:15:37

146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors

Episode 146

September 23, 2025

146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors

️ Episode 146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors In this episode of PaperCast Base by Base, we...

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00:15:56

145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD

Episode 145

September 22, 2025

145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD

️ Episode 145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD In this episode of PaperCast Base by Base, we...

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00:16:59

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