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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway

Episode 40

June 09, 2025

️ 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway

️ Episode 40: Lysosomal Proton Leak — Uncovering SLC7A11’s Role as an Unconventional H⁺ Transit Pathway In this episode of Base by Base, we...

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00:17:43

️ 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS

Episode 39

June 07, 2025

️ 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS

️ Episode 39: Whole-Genome Polygenic Score Inference — Fast and Memory-Efficient Algorithms for Scalable PRS In this episode of Base by Base, we dive...

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00:19:15

️ 38: Viral Journeys — Tracing the Ancestral Bat Origins of SARS-CoV and SARS-CoV-2

Episode 38

June 07, 2025

️ 38: Viral Journeys — Tracing the Ancestral Bat Origins of SARS-CoV and SARS-CoV-2

️ Episode 38: The Recency and Geographical Origins of Bat Viruses Ancestral to SARS-CoV and SARS-CoV-2 In this episode of Base by Base, we...

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00:20:29

️ 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics

Episode 37

June 06, 2025

️ 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics

️ Episode 37: Proteomic Clues — Prioritizing Functional Missense Variants with Chemoproteomics In this episode of Base by Base, we highlight a new study...

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00:23:07

️ 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome

Episode 36

June 06, 2025

️ 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome

️ Episode 36: Bi-allelic POPDC2 Variants: A Novel Autosomal Recessive Cardiac Syndrome In this episode of Base by Base, we discuss a groundbreaking study...

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00:18:31

️ 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes

Episode 35

June 06, 2025

️ 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes

️ Episode 35: Tracing the Evolutionary History of CCR5Δ32 — Insights from Ancient and Modern Genomes In this episode of Base by Base, we...

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00:18:20