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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models

Episode 126

September 03, 2025

126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models

️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of PaperCast Base by Base,...

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00:20:59

125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities

Episode 125

September 02, 2025

125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities

️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episode...

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00:22:46

124: Exploring the Omnigenic Architecture of Selected Complex Traits

Episode 124

September 01, 2025

124: Exploring the Omnigenic Architecture of Selected Complex Traits

️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researchers are...

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00:23:47

123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease

Episode 123

August 31, 2025

123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease

️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we explore how...

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00:18:12

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

Episode 122

August 30, 2025

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a study...

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00:19:57

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

Episode 121

August 29, 2025

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of PaperCast Base by Base,...

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00:19:02