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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations

Episode 62

July 01, 2025

️ 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations

️ Episode 62: Breaking Resistance — How BRCA2-Deficient Tumors Escape PARP Inhibition Without Reversion Mutations In this episode of Base by Base, we explore...

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00:17:00

️ 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay

Episode 61

June 30, 2025

️ 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay

️ Episode 61: Monkeypox on the Frontline — Developing Brazil’s First qPCR Diagnostic Assay In this episode of Base by Base, we trace the...

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00:22:43

️ 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features

Episode 60

June 30, 2025

️ 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features

️ Episode 60: Epi-PRS — A New Frontier in Polygenic Risk Prediction with Epigenomic Features In this episode of Base by Base, we explore...

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00:17:41

️ 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics

Episode 59

June 29, 2025

️ 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics

️ Episode 59: Building Trust — Redefining Participant and Community Engagement in Cancer Genomics In this episode of Base by Base, we dive into...

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00:22:55

️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

Episode 58

June 28, 2025

️ 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity

️ Episode 58: Aneuploid Cells and Cellular Battles — How Cell Interactions Shape Genome Integrity In this episode of Base by Base, we explore...

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00:22:04

️ 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

Episode 57

June 27, 2025

️ 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability

️ Episode 57: Low Uptake of Genetic Testing in Medicaid-Enrolled Children with ASD and Intellectual Disability In this episode of Base by Base, we...

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00:19:40