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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 16: Equity in Focus: Building a Truly Global Genomic Landscape

Episode 16

April 25, 2025

️ 16: Equity in Focus: Building a Truly Global Genomic Landscape

️ Episode 16: Equity in Focus: Building a Truly Global Genomic Landscape In this episode of Base by Base, we address one of the...

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00:15:52

️ 15: What Makes Us Human? Genetics from Neandertals to Now

Episode 15

April 25, 2025

️ 15: What Makes Us Human? Genetics from Neandertals to Now

️ Episode 15: What Makes Us Human? Genetics from Neandertals to Now In this episode of Base by Base, we travel back in time—over...

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00:20:07

️ 14: Beyond the Genome - Societal Value of National Genomics Programmes

Episode 14

April 25, 2025

️ 14: Beyond the Genome - Societal Value of National Genomics Programmes

️ Episode 14: Beyond the Genome: Societal Value of National Genomics Programmes In this episode of Base by Base, we discuss a thought-provoking report...

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00:25:44

️ 13: Decoding De Novo: A Multigenerational Benchmark for Human Mutation Rates

Episode 13

April 25, 2025

️ 13: Decoding De Novo: A Multigenerational Benchmark for Human Mutation Rates

️ Episode 13: Decoding De Novo: A Multigenerational Benchmark for Human Mutation Rates In this episode of Base by Base, we explore a monumental...

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00:19:34

️ 12: Repairing the Blueprint: Insights from MUTYH Structure and Cancer-Associated Variants

Episode 12

April 19, 2025

️ 12: Repairing the Blueprint: Insights from MUTYH Structure and Cancer-Associated Variants

️ Episode 12: Repairing the Blueprint: Insights from MUTYH Structure and Cancer-Associated Variants In this episode of Base by Base, we explore a pivotal...

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00:16:28

️ 11: Targeting Mitochondria: A Therapeutic Strategy for Dnmt3a-Mutant Clonal Hematopoiesis

Episode 11

April 19, 2025

️ 11: Targeting Mitochondria: A Therapeutic Strategy for Dnmt3a-Mutant Clonal Hematopoiesis

️ Episode 11: Targeting Mitochondria: A Therapeutic Strategy for Dnmt3a-Mutant Clonal Hematopoiesis In this episode of Base by Base, we dive into a compelling...

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00:19:15