Latest Episodes
Episode 451
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August 25, 2026
451: Prion protein lowering is disease-modifying across stages and strains
Minikel EV et al., Nucleic Acids Research - This study uses antisense oligonucleotides (ASOs) to lower prion protein (PrP) RNA in mice and shows...
00:24:36
![450: ASOs que reduzem PrP prolongam a sobrevida [PT]](https://episodes.castos.com/6857d0f4a3b5e4-25951952/images/2584855/c1a-p6xp7-wwn9k4vmu3dw-mfnf5a.png)
Episode 450
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August 24, 2026
450: ASOs que reduzem PrP prolongam a sobrevida [PT]
Raymond GJ et al., JCI Insight - This episode covers a 2019 study showing that sequence-specific antisense oligonucleotides (ASOs) targeting the prion protein (PrP)...
00:24:57
![449: siRNA divalente para doença priônica [PT]](https://episodes.castos.com/6857d0f4a3b5e4-25951952/images/2584848/c1a-p6xp7-xxmrdkd3tvg1-sjl07x.png)
Episode 449
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August 24, 2026
449: siRNA divalente para doença priônica [PT]
Gentile JE et al., Nucleic Acids Research - Discovery and preclinical development of divalent siRNA candidates targeting PRNP, identifying 2439-s4 as a potent, durable...
00:28:46
Episode 448
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August 23, 2026
448: PrP‑lowering ASOs prolong survival in prion‑infected mice
Raymond GJ et al., JCI Insight - This study tests antisense oligonucleotides (ASOs) targeting Prnp in wild‑type mice infected with RML prions and shows...
00:25:16
Episode 447
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August 23, 2026
447: Divalent siRNA for prion disease
Gentile JE et al., Nucleic Acids Research - This study develops and tests divalent siRNA molecules that lower prion protein (PrP) in the brain,...
00:23:33
Episode 446
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August 23, 2026
446: Cilia, Synuclein, and Survival: G51D Mice Reveal a Shared Parkinson’s Pathway
Lin Y‑E et al., PNAS - Knock‑in SncaG51D/G51D mice show selective loss of primary cilia in specific striatal interneurons, astrocytes, piriform cortex PV cells...
00:28:38