Latest Episodes
Episode 458
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September 10, 2026
458: Somatic or inherited? Reading TP53 risk from shared DNA
MacGregor et al., The American Journal of Human Genetics - Pathogenic TP53 variants found in blood have long been read as inherited Li-Fraumeni alleles,...
00:25:09
Episode 457
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September 09, 2026
457: A deletion that raises Alzheimer risk, a duplication that lowers it
Quenez O et al., The American Journal of Human Genetics - Rare copy-number variants were called from 22,319 exomes covering early-onset Alzheimer disease, late-onset...
00:24:15
Episode 456
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September 08, 2026
456: Beyond exons: where heritability hides as traits get more polygenic
Fuhrer J et al., The American Journal of Human Genetics - Across 34 complex traits and disorders, a MiXeR-based framework partitions SNP heritability over...
00:45:46
Episode 455
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September 07, 2026
455: Agentic genomics: the bottleneck moves from code to judgment
Corpas M et al., Cell Genomics - A Perspective arguing that autonomous AI agents which discover, configure and chain bioinformatics operations from natural-language instructions...
00:13:44
![454: Efavirenz retarda a doença priônica mexendo no colesterol do cérebro [PT]](https://episodes.castos.com/6857d0f4a3b5e4-25951952/images/2594804/c1a-p6xp7-5zrwq11jt74-ycoh4l.png)
Episode 454
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September 02, 2026
454: Efavirenz retarda a doença priônica mexendo no colesterol do cérebro [PT]
Ali T et al., JCI Insight - Um antirretroviral aprovado para HIV, dado por via oral em microdose, prolongou a sobrevida de camundongos que...
00:17:13
Episode 453
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August 31, 2026
453: Efavirenz slows sCJD progression by reshaping brain cholesterol
Ali T et al., JCI Insight - Repurposed low-dose efavirenz slowed disease progression and extended survival in tg650 mice inoculated with MM1 sCJD prions...
00:20:56