Latest Episodes
Episode 461
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September 24, 2026
461: Adult Ank3 loss quiets neurons and lowers a myelin protein
Yoon et al., Proceedings of the National Academy of Sciences - ANK3, which encodes the scaffolding protein ankyrin-G, is a major risk gene for...
00:24:55
Episode 460
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September 21, 2026
460: The lupus variant that also sharpens antiviral defense
Virolainen et al., The American Journal of Human Genetics - A lupus signal on chromosome 11p15 narrows to a coding haplotype in IRF7 that...
00:24:13
Episode 459
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September 13, 2026
459: Cerebral palsy genetics: 515 candidate genes, evidence for 89
Arterbery et al., The American Journal of Human Genetics - Hundreds of genes have been reported as causes of cerebral palsy, yet there is...
00:24:06
Episode 458
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September 10, 2026
458: Somatic or inherited? Reading TP53 risk from shared DNA
MacGregor et al., The American Journal of Human Genetics - Pathogenic TP53 variants found in blood have long been read as inherited Li-Fraumeni alleles,...
00:25:09
Episode 457
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September 09, 2026
457: A deletion that raises Alzheimer risk, a duplication that lowers it
Quenez O et al., The American Journal of Human Genetics - Rare copy-number variants were called from 22,319 exomes covering early-onset Alzheimer disease, late-onset...
00:24:15
Episode 456
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September 08, 2026
456: Beyond exons: where heritability hides as traits get more polygenic
Fuhrer J et al., The American Journal of Human Genetics - Across 34 complex traits and disorders, a MiXeR-based framework partitions SNP heritability over...
00:45:46