Latest Episodes
Episode 381
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June 01, 2026
381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)
Battistoni G et al., PNAS - This paper presents BALI, a light-driven method that writes combinatorial DNA spatial barcodes directly onto biomolecules in tissue...
00:26:00
Episode 380
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May 29, 2026
380: Prime-SGE maps drug-resistance variants at scale
Abadie FMC et al., Cell Genomics - Abadie et al. present prime‑SGE, a pooled prime‑editing framework that installs thousands of precise point mutations across...
00:11:38
Episode 379
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May 27, 2026
379: Long reads reveal hidden structural and repeat variation in autism
Mortazavi M et al., Cell Genomics - PaperCast Base by Base discusses a long-read whole-genome sequencing study of 267 individuals from 63 families that...
00:26:30
Episode 378
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May 26, 2026
378: Dominant-negative PSMB8 variants stall immunoproteasome assembly
Wijngaard R et al., The American Journal of Human Genetics - Researchers describe seven individuals with monoallelic PSMB8 missense variants that impair immunoproteasome assembly,...
00:23:06
Episode 377
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May 26, 2026
377: ProteomeLM — proteome-scale language modeling for interactomes and essential genes
Malbranke C et al., Proceedings of the National Academy of Sciences (PNAS) - ProteomeLM is a transformer-based language model trained on complete proteomes that...
00:26:09
Episode 376
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May 26, 2026
376: Pfh1's Balancing Act: Unwinding, Rewinding, and the Role of Mitochondrial SSB
Ortiz-Rodríguez M et al., Proceedings of the National Academy of Sciences (PNAS) - Single-molecule optical tweezers and fluorescence reveal how the S. pombe Pif1-family...
00:27:53