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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

347: Diffusive spreading across dynamic mitochondrial network architectures

Episode 347

April 19, 2026

347: Diffusive spreading across dynamic mitochondrial network architectures

Holta KB et al., Proceedings of the National Academy of Sciences (PNAS) - This episode explains a quantitative framework for diffusion on spatially embedded...

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00:23:30

346: Palindromes and RNA Self-Recognition

Episode 346

April 19, 2026

346: Palindromes and RNA Self-Recognition

Kimchi O et al., PNAS - This computational study shows that self-complementary RNA regions (palindromes) can drive sequence-specific homotypic clustering by enabling multivalent intermolecular...

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00:23:19

345: Genes of Prosody: Rhythm, Music, and Reading

Episode 345

April 17, 2026

345: Genes of Prosody: Rhythm, Music, and Reading

Scartozzi AC et al., Human Genetics and Genomics Advances - This episode reviews a GWAS of speech rhythm (prosody) perception using the TOPsy task...

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00:25:41

344: Homozygous TNNI3 p.Arg136* and severe pediatric restrictive cardiomyopathy

Episode 344

April 17, 2026

344: Homozygous TNNI3 p.Arg136* and severe pediatric restrictive cardiomyopathy

Kühnisch J et al., Human Genetics and Genomics Advances 7, 100598 (2026) - Case report and tissue analysis linking a homozygous TNNI3 nonsense variant...

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00:23:28

343: From Cats to Dogs: The Parvovirus Host Jump

Episode 343

April 15, 2026

343: From Cats to Dogs: The Parvovirus Host Jump

López-Astacio RA et al., PNAS - Analysis of 60 years of feline panleukopenia virus genomes traces the origins of canine parvovirus, identifies vaccine-derived sequences,...

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00:13:48

342: Modular MPRA Reveals Context-Dependent Regulation at T2D Loci

Episode 342

April 14, 2026

342: Modular MPRA Reveals Context-Dependent Regulation at T2D Loci

Tovar A et al., Human Genetics and Genomics Advances - This episode examines a study that used a modular MPRA to test ~11,656 genomic...

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00:17:24

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