Latest Episodes
Episode 475
•
November 05, 2026
475: A Cell Line Fitness Score Predicts Cancer Risk in Li-Fraumeni Syndrome
Penkert J et al., The American Journal of Human Genetics - Carriers of disease-causing TP53 variants range from mild to severe cancer phenotypes. Using...
00:09:57
Episode 474
•
November 04, 2026
474: Two collagen genes, two different risks
Tzoumkas K et al., The American Journal of Human Genetics - COL4A3 and COL4A4 are paralogous genes that build the same collagen IV network...
00:19:39
Episode 473
•
November 03, 2026
473: Sixty years of cells that stop dividing
Klaver M et al., The EMBO Journal - In 1961, Hayflick and Moorhead showed that normal human fibroblasts divide only a finite number of...
00:19:38
Episode 472
•
November 02, 2026
472: 490,319 genomes that fill the gaps in genetic studies
Wienbrandt L et al., Nature Genetics - Most genetic studies read only a fraction of the genome and infer the rest from a reference...
00:17:57
Episode 471
•
October 30, 2026
471: How cancer treatment picks winners among mutant clones in the normal esophagus
Fowler J et al., Nature Genetics - Normal esophageal lining is a patchwork of mutant clones that compete for space as we age. This...
00:17:54
Episode 470
•
October 29, 2026
470: The hidden swaps CRISPR leaves between sister chromosomes
Chovanec P et al., eLife - When CRISPR/Cas9 cuts DNA, editing is usually judged by the small insertions and deletions left at the break....
00:17:23