Latest Episodes
Episode 465
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October 11, 2026
465: When a lysosomal storage gene shows up only in the retina
Lin et al., The American Journal of Human Genetics - Bi-allelic variants in IDUA classically cause mucopolysaccharidosis type I, a lysosomal storage disorder that...
00:20:03
Episode 464
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October 06, 2026
464: Burning fat while sparing muscle on GLP-1 drugs, in mice
Thorne et al., Proceedings of the National Academy of Sciences - GLP-1 receptor agonists such as semaglutide produce large weight loss, but part of...
00:18:20
Episode 463
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October 04, 2026
463: Why brain traits leave faint, common genetic signals
Zhu et al., Proceedings of the National Academy of Sciences - Genome-wide studies of schizophrenia and other psychiatric disorders find hundreds of hits, yet...
00:18:21
Episode 462
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September 30, 2026
462: A vessel gene tied to AMD dims low-light vision in mice
Cheng et al., Proceedings of the National Academy of Sciences - Genome-wide studies have found dozens of risk loci for age-related macular degeneration, but...
00:20:10
Episode 461
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September 24, 2026
461: Adult Ank3 loss quiets neurons and lowers a myelin protein
Yoon et al., Proceedings of the National Academy of Sciences - ANK3, which encodes the scaffolding protein ankyrin-G, is a major risk gene for...
00:24:55
Episode 460
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September 21, 2026
460: The lupus variant that also sharpens antiviral defense
Virolainen et al., The American Journal of Human Genetics - A lupus signal on chromosome 11p15 narrows to a coding haplotype in IRF7 that...
00:24:13