Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

Episode 122

August 30, 2025

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a study...

Play

00:19:57

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

Episode 121

August 29, 2025

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of PaperCast Base by Base,...

Play

00:19:02

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

Episode 120

August 28, 2025

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare heterozygous...

Play

00:22:30

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

Episode 119

August 27, 2025

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore how stabilizing...

Play

00:18:35

118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Episode 118

August 26, 2025

118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base,...

Play

00:19:11

117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection

Episode 117

August 25, 2025

117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection

️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore how viral...

Play

00:16:00