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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Episode 168

October 15, 2025

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

️ Episode 168: Low circulating miR-190a-5p predicts progression of chronic kidney disease In this episode of PaperCast Base by Base, we explore how unbiased...

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00:19:10

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

Episode 167

October 14, 2025

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution In this episode of PaperCast Base by Base, we explore a Cell...

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00:21:40

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

Episode 166

October 13, 2025

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments In this episode of PaperCast Base by Base, we explore...

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00:13:37

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Episode 165

October 12, 2025

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

️ Episode 165: Protist Genomics: Key to Understanding Eukaryotic Evolution In this episode of PaperCast Base by Base, we explore how accelerating protist genomics—spanning...

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00:19:24

164: m6A in the coding sequence: linking deposition, translation, and decay

Episode 164

October 11, 2025

164: m6A in the coding sequence: linking deposition, translation, and decay

️ Episode 164: m6A in the coding sequence: linking deposition, translation, and decay In this episode of PaperCast Base by Base, we explore how...

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00:14:46

163: Animal origins: looping back in time

Episode 1

October 10, 2025

163: Animal origins: looping back in time

️ Episode 163: Animal origins: looping back in time In this episode of PaperCast Base by Base, we explore how chromatin folding mechanisms emerged...

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00:14:18