Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

Episode 76

July 15, 2025

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage...

Play

00:13:22

️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years

Episode 75

July 14, 2025

️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years

️ Episode 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years In this episode of PaperCast Base by Base, we explore a large-scale...

Play

00:14:56

️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR

Episode 74

July 13, 2025

️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR

️ Episode 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR In this episode of PaperCast Base by Base, we explore a unified computational framework...

Play

00:20:10

️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield

Episode 73

July 12, 2025

️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield

️ Episode 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield In this episode of PaperCast Base by Base, we explore a study...

Play

00:15:55

️ 72: The POC5 Syndrome — A Ciliopathy Linking Retina, Muscles and Metabolism

Episode 72

July 11, 2025

️ 72: The POC5 Syndrome — A Ciliopathy Linking Retina, Muscles and Metabolism

️ Episode 72: The POC5 Syndrome — A Ciliopathy Linking Retina, Muscles and Metabolism In this episode of Base by Base, we explore a...

Play

00:19:44

️ 71: ELFN1 Deficiency Disorder — Mechanistic Basis and Phenotypic Spectrum of a Neurodevelopmental Disorder with Epilepsy

Episode 71

July 10, 2025

️ 71: ELFN1 Deficiency Disorder — Mechanistic Basis and Phenotypic Spectrum of a Neurodevelopmental Disorder with Epilepsy

️ Episode 71: ELFN1 Deficiency Disorder — Mechanistic Basis and Phenotypic Spectrum of a Neurodevelopmental Disorder with Epilepsy In this episode of Base by...

Play

00:25:16