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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk

Episode 134

September 11, 2025

134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk

️ Episode 134: Single-Cell Maps Link Intestinal Metaplasia to Esophageal Adenocarcinoma Risk In this episode of PaperCast Base by Base, we explore how single-cell...

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00:15:47

133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth

Episode 133

September 10, 2025

133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth

️ Episode 133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth In this episode of PaperCast Base by Base, we explore how long‑read...

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00:24:31

132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer

Episode 132

September 09, 2025

132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer

️ Episode 132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer In this episode of PaperCast Base by Base, we explore how...

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00:20:35

131: pBI143: The Human Gut’s Hidden Heavyweight

Episode 131

September 08, 2025

131: pBI143: The Human Gut’s Hidden Heavyweight

️ Episode 131: pBI143: The Human Gut’s Hidden Heavyweight In this episode of PaperCast Base by Base, we explore how a tiny 2.7 kb...

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00:17:59

130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution

Episode 130

September 07, 2025

130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution

️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this episode of PaperCast...

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00:20:24

129: Structural variation and diversification of the NPIP gene family from the human pangenome

Episode 129

September 06, 2025

129: Structural variation and diversification of the NPIP gene family from the human pangenome

️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base,...

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00:22:11