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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities

Episode 162

October 09, 2025

162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities

️ Episode 162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities In this episode of PaperCast Base by Base, we explore how...

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00:20:15

161: Decoding Genomic Landscapes of Introgression

Episode 161

October 08, 2025

161: Decoding Genomic Landscapes of Introgression

️ Episode 161: Decoding Genomic Landscapes of Introgression In this episode of PaperCast Base by Base, we explore how modern population genetics dissects the...

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00:20:55

160: The Long‑Read Leap in Single‑Cell Omics

October 07, 2025

160: The Long‑Read Leap in Single‑Cell Omics

️ Episode 160: The Long‑Read Leap in Single‑Cell Omics In this episode of PaperCast Base by Base, we explore how long‑read, single‑molecule sequencing has...

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00:15:36

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Episode 159

October 06, 2025

159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research

️ Episode 159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research In this episode of PaperCast Base by Base, we explore how modern...

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00:15:56

158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?

Episode 158

October 05, 2025

158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost?

️ Episode 158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost? In this episode of PaperCast Base by Base, we explore...

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00:22:35

157: Synthetic gametes and the non-identity problem: the babies of tomorrow

Episode 157

October 04, 2025

157: Synthetic gametes and the non-identity problem: the babies of tomorrow

️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow In this episode of PaperCast Base by Base, we explore how...

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00:14:32