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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine

Episode 48

June 16, 2025

️ 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine

️ Episode 48: Mainstreaming Genetic Testing — A Conceptual Framework for Expanding Genomic Medicine In this episode of Base by Base, we explore an...

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00:16:11

️ 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network

Episode 47

June 16, 2025

️ 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network

️ Episode 47: Selectivity and Promiscuity — Decoding the Human Chemokine-GPCR Network In this episode of Base by Base, we explore a systems-level framework...

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00:22:38

️ 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay

Episode 46

June 14, 2025

️ 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay

️ Episode 46: Pan-Epitranscriptomic Control — How tRNA and m6A Interact to Regulate mRNA Decay In this episode of Base by Base, we delve...

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00:20:34

️ 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments

Episode 45

June 12, 2025

️ 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments

️ Episode 45: Probing Nucleolar Mechanics — RNA-Dependent Viscoelasticity of Nucleolar Subcompartments In this episode of Base por Base, we delve into a groundbreaking...

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00:20:53

️ 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme

Episode 44

June 12, 2025

️ 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme

️ Episode 44: Proofreading Precision — Unveiling the Cryo-EM Mechanism of Human DNA Polymerase ε Holoenzyme In this episode of Base per Base, we...

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00:19:02

️ 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

Episode 43

June 11, 2025

️ 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes

️ Episode 43: Personalized Molecular Signatures of Insulin Resistance and Type 2 Diabetes In this episode of Base by Base, we explore the groundbreaking...

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00:19:33