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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer

Episode 78

July 17, 2025

️ 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer

️ Episode 78: Interactions between TTYH2 and APOE Facilitate Endosomal Lipid Transfer In this episode of PaperCast Base by Base, we explore the discovery...

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00:14:53

️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity

Episode 77

July 16, 2025

️ 77: Range Extender: Unlocking Long-Distance Enhancer Activity

️ Episode 77: Range Extender: Unlocking Long-Distance Enhancer Activity In this episode of PaperCast Base by Base, we explore the discovery and functional characterization...

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00:16:31

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

Episode 76

July 15, 2025

️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian

️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage...

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00:13:22

️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years

Episode 75

July 14, 2025

️ 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years

️ Episode 75: Metabolic Shaping of Enzyme Structures Over 400 Million Years In this episode of PaperCast Base by Base, we explore a large-scale...

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00:14:56

️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR

Episode 74

July 13, 2025

️ 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR

️ Episode 74: Benchmarking T Cell Receptor–Epitope Predictors with ePytope-TCR In this episode of PaperCast Base by Base, we explore a unified computational framework...

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00:20:10

️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield

Episode 73

July 12, 2025

️ 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield

️ Episode 73: Assessing Family History in Dementia Genetics: Enhancing Diagnostic Yield In this episode of PaperCast Base by Base, we explore a study...

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00:15:55