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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 68: Indels Empower Antiviral Proteins to Achieve Functional Novelty Beyond Missense Mutations

Episode 68

July 07, 2025

️ 68: Indels Empower Antiviral Proteins to Achieve Functional Novelty Beyond Missense Mutations

️ Episode 68: Indels Empower Antiviral Proteins to Achieve Functional Novelty Beyond Missense Mutations In this episode of Base by Base, we dive into...

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00:16:04

️ 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease

Episode 67

July 06, 2025

️ 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease

️ Episode 67: Smarter Signals — How Multimodal AI Boosts Genetic Prediction of Heart Disease In this episode of Base por Base, we delve...

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00:14:47

️ 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework

Episode 66

July 05, 2025

️ 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework

️ Episode 66: Mainstreaming Clinical Genetic Testing — A Conceptual Framework In this episode of Base por Base, we delve into the consensus-based framework...

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00:20:02

️ 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome

Episode 65

July 04, 2025

️ 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome

️ Episode 65: Uncovering Hidden Splice Defects — Genome Sequencing and Group-Enrichment in Marfan Syndrome In this episode of Base por Base, we delve...

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00:18:37

️ 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy

Episode 64

July 03, 2025

️ 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy

️ Episode 64: Pisces — A Multi-Modal Framework for Predicting Drug Combination Synergy In this episode of Base by Base, we delve into a...

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00:23:10

️ 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets

Episode 63

July 02, 2025

️ 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets

️ Episode 63: Sampling Scale Matters — A Spatial Model for Rare Variant Discovery in Biobank-Scale Datasets In this episode of Base by Base,...

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00:23:10