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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

Episode 114

August 22, 2025

114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique

️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique In this episode of PaperCast Base by...

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00:16:31

113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations

Episode 113

August 21, 2025

113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations

️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations In this episode of PaperCast Base by Base, we explore how...

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00:22:08

112: Local Genetic Sex Differences in Quantitative Traits

Episode 112

August 20, 2025

112: Local Genetic Sex Differences in Quantitative Traits

️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences between...

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00:21:16

111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer

Episode 111

August 19, 2025

111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer

️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore...

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00:17:06

110: Whole-exome sequencing identifies new schizophrenia risk genes

Episode 110

August 18, 2025

110: Whole-exome sequencing identifies new schizophrenia risk genes

️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing...

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00:20:31

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

Episode 109

August 17, 2025

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA...

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00:18:10