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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

Episode 120

August 28, 2025

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare heterozygous...

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00:22:30

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

Episode 119

August 27, 2025

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore how stabilizing...

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00:18:35

118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

Episode 118

August 26, 2025

118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B

️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base,...

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00:19:11

117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection

Episode 117

August 25, 2025

117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection

️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore how viral...

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00:16:00

116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation

Episode 116

August 24, 2025

116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation

️ Episode 116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation In this episode of PaperCast Base by Base, we explore how a seemingly...

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00:15:53

115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System

Episode 115

August 24, 2025

115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System

Episode 115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System In this episode of PaperCast Base by...

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00:15:24