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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

110: Whole-exome sequencing identifies new schizophrenia risk genes

Episode 110

August 18, 2025

110: Whole-exome sequencing identifies new schizophrenia risk genes

️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing...

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00:20:31

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

Episode 109

August 17, 2025

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA...

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00:18:10

108: Epigenome Editing Reverses HBG Silencing

Episode 108

August 16, 2025

108: Epigenome Editing Reverses HBG Silencing

️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylation...

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00:20:53

107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

Episode 107

August 15, 2025

107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a...

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00:19:07

106: Decoding Brain Maps for Pharmacotranscriptomics

Episode 106

August 14, 2025

106: Decoding Brain Maps for Pharmacotranscriptomics

️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics In this episode of PaperCast Base by Base, we explore a Nature Communications study, that introduces...

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00:19:25

105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance

Episode 105

August 13, 2025

105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance

️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance In this episode of PaperCast Base by Base, we explore groundbreaking...

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00:18:28

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