Latest Episodes
Episode 330
•
March 30, 2026
330: 5ULTRA: Mapping 5′ UTR variants that alter protein translation
Chaldebas M et al., The American Journal of Human Genetics - Chaldebas et al. present 5ULTRA, a computational pipeline that integrates uORF databases, Kozak-motif...
00:22:56
Episode 329
•
March 30, 2026
329: Large future genetic diversity losses predicted despite habitat protection
Mualim KS et al., Proceedings of the National Academy of Sciences - This study develops spatiotemporal population-genetic models calibrated with genomic data to predict...
00:22:16
Episode 328
•
March 27, 2026
328: Variant selection boosts R2 for haptoglobin (HP) in cis‑Mendelian randomization
Zhou A et al., Human Genetics and Genomics Advances - Comparing LD‑pruning, COJO, SuSiE and PCA in haptoglobin (HP) cis‑region data, the study finds...
00:23:39
Episode 327
•
March 27, 2026
327: Bi-allelic ATG12 variants impair ATG12-ATG5 conjugation, LC3 lipidation and neural development
Lambton J et al., The American Journal of Human Genetics - Bi-allelic ATG12 variants disrupt ATG12‑ATG5 conjugation and LC3 lipidation, impairing autophagy in patient...
00:19:17
Episode 326
•
March 25, 2026
326: DUO-1 protects REC-8 cohesin and synaptonemal complex stability in Caenorhabditis elegans meiosis
Strand LG et al., Proc. Natl. Acad. Sci. U.S.A - In C. elegans germline, the deubiquitinase DUO-1 is required for assembly and active maintenance...
00:24:34
Episode 325
•
March 24, 2026
325: cis-pcQTL mapping reveals allelic proxitropy across neighboring human genes
Lawrence et al., The American Journal of Human Genetics - Using a cis-principal-component (pcQTL) approach in human GTEx tissues, the authors uncover novel multi-gene...
00:23:57