Latest Episodes
Episode 415
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July 18, 2026
415: ERG Unlocked: Targeting the PNT Domain with PBITE-1
PNAS - This episode breaks down a PNAS study that identifies a druggable pocket in the ERG transcription factor PNT domain and describes PBITE-1,...
00:25:00
Episode 414
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July 17, 2026
414: Durability of Cas9 Gene Drives in Anopheles: A 2‑Year Cage Study
Carballar-Lejarazúa R et al., PNAS (2026) - This episode summarizes a 2-year, 35-generation multireplicate cage trial evaluating three autonomous Cas9/gRNA gene-drive strains (AcTP13, AcTP43...
00:31:09
Episode 413
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July 12, 2026
413: Rpc34 WH2 dynamics in RNA polymerase III
Wu J-S et al., PNAS - A PNAS study using smFRET and nano-positioning triangulation maps dynamic positioning of the Rpc34 WH2 domain in yeast...
00:15:24
Episode 412
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July 12, 2026
412: Fault Lines in Forensic Proficiency Testing
Scurich N et al., PNAS - A concise breakdown of a PNAS perspective that analyzes forensic proficiency testing practices using the 2023 CTS firearms...
00:28:15
Episode 411
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July 09, 2026
411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity
Nihata A et al., PNAS - This PNAS study describes the development of EKV, a humanized dividing cell line that propagates bona fide sporadic...
00:26:33
Episode 410
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July 08, 2026
410: Nucleotide diversity is a poor predictor of short-term adaptive potential
Abson KL et al., PNAS - A cross-species synthesis and theory paper showing that simple molecular diversity metrics poorly predict short-term adaptive potential. The...
00:21:48