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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

225: VRK-1 and BAF-1 release meiotic chromosomes

Episode 225

December 10, 2025

225: VRK-1 and BAF-1 release meiotic chromosomes

️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove...

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00:17:13

224: AntennAlive — wireless in-body sensing with engineered bacteria

Episode 224

December 10, 2025

224: AntennAlive — wireless in-body sensing with engineered bacteria

️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free...

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00:18:41

223: Torsion Regulates DNA Replication Stalling and Restart

Episode 223

December 09, 2025

223: Torsion Regulates DNA Replication Stalling and Restart

️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical...

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00:16:26

222: snaR-A hijacks splicing to drive proliferation

Episode 222

December 08, 2025

222: snaR-A hijacks splicing to drive proliferation

️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the...

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00:17:57

221: Allele-resolved nanopore tour of the human placental methylome

Episode 221

December 07, 2025

221: Allele-resolved nanopore tour of the human placental methylome

️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased long-read...

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00:20:23

220: The AML cellular state space reveals NPM1 immune evasion subtypes

Episode 220

December 06, 2025

220: The AML cellular state space reveals NPM1 immune evasion subtypes

️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and...

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00:15:48