Latest Episodes
Episode 271
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January 25, 2026
271: Rising EA PGI prediction of educational attainment across 1946–1970 British birth cohorts and socioeconomic interaction
Morris TT et al., PNAS - EA and cognition polygenic indexes (PGIs) in three British birth cohorts show EA PGI associations with years of...
00:19:51
Episode 270
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January 25, 2026
270: Human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negatively supercoiled DNA measured by optical tweezers
Spakmana D et al., H., Hickson I. D., Peterman E. J. G., Wuite G. J. L., King G. A. Mechanistic basis for relaxation of...
00:22:00
Episode 269
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January 24, 2026
269: Mlh1–Pms1 endonuclease creates single-strand gaps to excise mispairs in S. cerevisiae MMR
Palacio T et al., PNAS - Reconstituted Saccharomyces cerevisiae mismatch repair shows the Mlh1–Pms1 endonuclease directly generates single-strand gaps to excise mispairs independent of...
00:20:45
Episode 268
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January 23, 2026
268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment
Cail RC et al., PNAS - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts the super-relaxed state and increases...
00:22:05
Episode 267
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January 22, 2026
267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange
Englander SW et al., PNAS - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct base-pair opening modes: single-base microsecond...
00:21:20
Episode 266
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January 21, 2026
266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks
Vatsa A et al., PNAS - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral transcription and replication, acting via...
00:17:03