Latest Episodes
Episode 439
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August 11, 2026
439: Coembedding Sequence and Structure: CLSS Maps the Protein Universe
Longo LM et al., PNAS - This episode summarizes a PNAS study introducing CLSS, a contrastive two-tower protein language model that coembeds domain sequences,...
00:23:08
Episode 438
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August 10, 2026
438: Mapping AIRE: a proactive atlas of 9,790 missense variants
Axakova A et al., The American Journal of Human Genetics - Axakova et al. generated a variant effect map for AIRE using an insulin‑promoter...
00:24:02
Episode 437
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August 09, 2026
437: Cell villages and Dirichlet modeling map human cell fitness genetics
Hanson C et al., The American Journal of Human Genetics - Hanson et al. combine pooled multi-donor human neural progenitor cell "villages" with Townlet,...
00:28:03
Episode 436
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August 08, 2026
436: KIAP4 and the ARND family: building the Leishmania adhesion plaque
Owino BO et al., PNAS - Using TurboID proximity proteomics and microscopy, researchers identify KIAP4 as the canonical member of a conserved Adhesion Related...
00:24:51
Episode 435
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August 07, 2026
435: E. coli TGT binds two tRNAs — cryo-EM reveals dual engagement
Ember M et al., PNAS - This episode examines a cryo-EM study of Escherichia coli tRNA-guanine transglycosylase (TGT) that solves the enzyme structure and...
00:19:03
Episode 434
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August 06, 2026
434: High‑coverage genomes recast Japan's prehistoric demography
Ishiya K et al., PNAS - This episode examines a PNAS study that reports two high-coverage ancient human genomes from mainland Japan (an Initial...
00:27:07