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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

201: Sex, Smoking, and Somatic Selection in the Bladder

Episode 201

November 17, 2025

201: Sex, Smoking, and Somatic Selection in the Bladder

️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex...

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00:14:52

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Episode 200

November 16, 2025

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

️ Episode 200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline In this episode of PaperCast Base by Base, we explore how...

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00:18:48

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

Episode 199

November 15, 2025

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

️ Episode 199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity In this episode of PaperCast Base by Base, we explore how loss-of-function...

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00:13:57

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Episode 1

November 14, 2025

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

️ Episode 198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells In this episode of PaperCast Base by Base, we explore how physical...

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00:15:47

197: Somatic Mutation and Selection at Population Scale

Episode 197

November 13, 2025

197: Somatic Mutation and Selection at Population Scale

️ Episode 197: Somatic Mutation and Selection at Population Scale In this episode of PaperCast Base by Base, we explore how ultra-accurate NanoSeq duplex...

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00:15:11

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Episode 196

November 12, 2025

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

️ Episode 196: Impact of Chromatin Accessibility QTLs Across Immune Contexts In this episode of PaperCast Base by Base, we explore how single-cell chromatin...

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00:16:37

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