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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

425: BEAM: Bayesian reconstruction of metastatic migration histories

Episode 425

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July 23, 2026

425: BEAM: Bayesian reconstruction of metastatic migration histories

Staklinski SJ et al., Cell Genomics 6, 101193 (2026) - This episode explores BEAM, a Bayesian framework built on BEAST 2 that jointly infers...

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00:23:31

424: LECA's Ancient Interactome and Modern Disease

Episode 424

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July 23, 2026

424: LECA's Ancient Interactome and Modern Disease

Cox RM et al., Cell Genomics 6, 101254 - Cox et al. reconstruct a conserved protein interaction network for the last eukaryotic common ancestor...

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00:12:03

423: How GRN Topology Shapes the Genetic Architecture of Expression

Episode 423

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July 22, 2026

423: How GRN Topology Shapes the Genetic Architecture of Expression

Aguirre M et al., Cell Genomics - Aguirre et al. use simulated gene regulatory networks and a linear structural equation model to show how...

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00:25:10

422: Germline rDNA Variants and Human Complex Traits

Episode 422

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July 22, 2026

422: Germline rDNA Variants and Human Complex Traits

Rodriguez-Algarra F et al., Cell Genomics - This episode examines a large-scale analysis of germline ribosomal DNA (rDNA) variation in ~500,000 UK Biobank genomes...

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00:20:13

421: Pre-existing Cell States Predict Multi-Treatment Resistance

Episode 421

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July 22, 2026

421: Pre-existing Cell States Predict Multi-Treatment Resistance

Schaff DL et al., Cell Genomics - Schaff et al. use multi-treatment clonal tracing combined with single-cell RNA-seq to show that rare, pre-existing transcriptional...

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00:24:03

420: NOTCH2NL duplications: diversity, regulation, and human-specific changes

Episode 420

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July 21, 2026

420: NOTCH2NL duplications: diversity, regulation, and human-specific changes

Real TD et al., Cell Genomics - This episode examines a long-read sequencing study that resolves the complex NOTCH2NL segmental duplications on human chromosome...

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00:22:05

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