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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

247: Genome graphs reveal structural variation in M. tuberculosis

Episode 247

January 02, 2026

247: Genome graphs reveal structural variation in M. tuberculosis

️ Episode 247: Genome graphs reveal structural variation in M. tuberculosis In this episode of PaperCast Base by Base, we explore Long-read assemblies and...

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00:21:27

246: SV2A structural pharmacology and allosteric occlusion

Episode 246

January 01, 2026

246: SV2A structural pharmacology and allosteric occlusion

️ Episode 246: SV2A structural pharmacology and allosteric occlusion In this episode of PaperCast Base by Base, we explore High-resolution cryo-EM structures of human...

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00:16:44

245: Benchmarking DNA foundation models

Episode 245

December 31, 2025

245: Benchmarking DNA foundation models

️ Episode 245: Benchmarking DNA foundation models In this episode of PaperCast Base by Base, we explore A comprehensive, unbiased benchmark compares five DNA...

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00:19:10

244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis

Episode 244

December 30, 2025

244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis

️ Episode 244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis In this episode of PaperCast Base by Base, we...

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00:17:38

243: Genome-wide UVB GxE study finds 162 vitamin D variants

Episode 243

December 29, 2025

243: Genome-wide UVB GxE study finds 162 vitamin D variants

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS...

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00:17:41

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

Episode 242

December 28, 2025

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramuscular...

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00:17:40

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