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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

391: The Kaufmann Protocol — Why We Age and How to Stop It

Episode 391

June 12, 2026

391: The Kaufmann Protocol — Why We Age and How to Stop It

Dr. Sandra Kaufmann, The Kaufmann Anti-Aging Institute - Dr. Sandra Kaufmann — physician, scientist and athlete — set out to understand aging and fight...

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01:06:28

390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense

Episode 390

June 09, 2026

390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense

Gätgens C et al., PNAS - This episode examines how DNA-intercalating molecules like daunorubicin block bacteriophage infection at an early stage, causing an abortive-infection-like...

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00:22:59

389: Crotonylation impedes c-Myc oncogenic activity

Episode 389

June 09, 2026

389: Crotonylation impedes c-Myc oncogenic activity

PNAS - This study identifies crotonylation as a posttranslational modification of c-Myc that reduces its transcriptional and oncogenic activity. Key lysines K289 and K298...

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00:25:28

388: Base by Base | Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis

Episode 388

June 09, 2026

388: Base by Base | Episode 388 — In situ CAR‑macrophage alleviates liver fibrosis

Huang X et al., Proceedings of the National Academy of Sciences (PNAS) - This episode summarizes a PNAS study reporting CD163‑targeted lipid nanoparticles that...

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00:21:01

387: Homotypic Dengue Reinfections and Long-Term Antibody Decay

Episode 387

June 09, 2026

387: Homotypic Dengue Reinfections and Long-Term Antibody Decay

Andrade J et al., PNAS - Analysis of three long-term cohorts in the Philippines and Thailand shows antibody titers wane over years and that...

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00:21:36

386: Genome Doubling and the Bioeconomy

Episode 386

June 05, 2026

386: Genome Doubling and the Bioeconomy

Peeters MKR et al., Proceedings of the National Academy of Sciences (PNAS) - A perspective outlining how genome doubling (polyploidy) reshapes genomes, phenotypes, and...

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00:24:26

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