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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

207: Semantic Design of de novo Genes with Evo

Episode 207

November 24, 2025

207: Semantic Design of de novo Genes with Evo

️ Episode 207: Semantic Design of de novo Genes with Evo In this episode of PaperCast Base by Base, we explore how a genomic...

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00:15:05

206: Wild Birds and the North American H5N1 Epizootic

Episode 206

November 22, 2025

206: Wild Birds and the North American H5N1 Epizootic

️ Episode 206: Wild Birds and the North American H5N1 Epizootic In this episode of PaperCast Base by Base, we explore how wild migratory...

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00:17:17

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Episode 205

November 21, 2025

205: Ancient RNA Expression Profiles from the Woolly Mammoth

️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth In this episode of PaperCast Base by Base, we explore how ancient RNA...

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00:17:19

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

Episode 204

November 20, 2025

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators In this episode of PaperCast Base by Base, we explore how the StealTHY CRISPR platform...

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00:16:39

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Episode 203

November 19, 2025

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and...

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00:18:08

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Episode 202

November 19, 2025

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues In this episode of PaperCast Base by Base, we explore how Stereo-seq...

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00:17:08