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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

253: Nap1 and histone acetylation tune chromatin condensates

Episode 253

January 08, 2026

253: Nap1 and histone acetylation tune chromatin condensates

Gao J et al., Nat Commun - H4 tail lysine residues drive liquid-liquid phase separation of 12‑mer nucleosome arrays, while H3 tail acetylation and...

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00:20:26

252: Keratinocytes to cSCC: genetic steps

Episode 252

January 07, 2026

252: Keratinocytes to cSCC: genetic steps

️ Episode 252: Keratinocytes to cSCC: genetic steps In this episode of PaperCast Base by Base, we explore Single-cell and spatial multi-omic profiling maps...

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00:18:13

251: MuSCs, laminin-α2 and LAMA2 MD

Episode 251

January 06, 2026

251: MuSCs, laminin-α2 and LAMA2 MD

️ Episode 251: MuSCs, laminin-α2 and LAMA2 MD In this episode of PaperCast Base by Base, we explore Activated muscle stem cells express and...

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00:19:00

250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ

Episode 250

January 05, 2026

250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ

️ Episode 250: CIP2A–TOPBP1: Mitotic repair via MiDAS and MMEJ In this episode of PaperCast Base by Base, we explore This study shows the...

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00:18:16

249: PCM1 links centrosome asymmetry to endosome dynamics

Episode 249

January 04, 2026

249: PCM1 links centrosome asymmetry to endosome dynamics

️ Episode 249: PCM1 links centrosome asymmetry to endosome dynamics In this episode of PaperCast Base by Base, we explore In developing neural progenitors...

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00:20:40

248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation

Episode 248

January 03, 2026

248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation

️ Episode 248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation In this episode of PaperCast Base by Base, we explore Disruption of...

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00:21:12