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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

213: BRAIN-MAGNET: a functional atlas for non-coding variants

Episode 213

November 29, 2025

213: BRAIN-MAGNET: a functional atlas for non-coding variants

️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples a ChIP-STARR-seq...

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00:20:29

212: Zonal control of mutant β-catenin tumorigenesis

Episode 212

November 28, 2025

212: Zonal control of mutant β-catenin tumorigenesis

️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer...

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00:16:47

211: Retention Elements in Cancer Cells

Episode 211

November 27, 2025

211: Retention Elements in Cancer Cells

️ Episode 211: Retention Elements in Cancer Cells In this episode of PaperCast Base by Base, we explore the discovery of genetic elements that...

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00:19:30

210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma

Episode 210

November 26, 2025

210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma

️ Episode 210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma In this episode of PaperCast Base by Base, we explore how tumour-reactive CD8...

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00:18:45

209: PERT: Prime Editing tRNAs for Nonsense Mutations

Episode 209

November 25, 2025

209: PERT: Prime Editing tRNAs for Nonsense Mutations

️ Episode 209: PERT: Prime Editing tRNAs for Nonsense Mutations In this episode of PaperCast Base by Base, we explore how prime editing can...

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00:16:54

208: ZAK, Collided Ribosomes, and the Stress Switch

Episode 208

November 24, 2025

208: ZAK, Collided Ribosomes, and the Stress Switch

️ Episode 208: ZAK, Collided Ribosomes, and the Stress Switch In this episode of PaperCast Base by Base, we explore how collided ribosomes activate...

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00:15:55