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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Episode 409

July 07, 2026

409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Shin J et al., PNAS - This episode examines a large transcriptome compendium (PRECISE-NP881) that profiles E. coli K-12 MG1655 across 43 carbon substrates....

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00:27:15

408: Tau, mitochondria, and the fusion switch

Episode 408

July 06, 2026

408: Tau, mitochondria, and the fusion switch

Tsakiria E et al., Proceedings of the National Academy of Sciences (PNAS) - Using Tau knockout mice and the C. elegans PTL-1 deletion, this...

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00:24:42

407: SLC11A2 withholds metals from Salmonella in the gut epithelium

Episode 407

July 05, 2026

407: SLC11A2 withholds metals from Salmonella in the gut epithelium

Norberg ES et al., Proceedings of the National Academy of Sciences - Using metal‑responsive fluorescent Salmonella reporters, calf intestinal loops, and CRISPR edited epithelial...

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00:21:54

406: Temperature & Age Shape Gut Susceptibility to HCoV-229E

Episode 406

July 01, 2026

406: Temperature & Age Shape Gut Susceptibility to HCoV-229E

Synowiec A et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study using fetal, pediatric, and adult...

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00:19:53

405: PRDM9 and the Hotspot Trade-off

Episode 405

July 01, 2026

405: PRDM9 and the Hotspot Trade-off

Úbeda F et al., Proceedings of the National Academy of Sciences (PNAS) - A population-genetic model explains why sequence-specific PRDM9-guided recombination hotspots can evolve...

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00:23:33

404: RUNA Reveals Surface DNA on Exosomes

Episode 404

June 30, 2026

404: RUNA Reveals Surface DNA on Exosomes

Bošković F et al., Proceedings of the National Academy of Sciences - This study introduces RUNA, a reversible chemistry that selectively labels uridine/thymidine to...

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00:21:02