Latest Episodes
Episode 443
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August 18, 2026
443: 5D‑ASO boosts exon 51 skipping and restores dystrophin in DMD models
Feng P et al., PNAS - This paper describes a bipartite antisense oligonucleotide (5D‑ASO) design that appends a short 5′ splice site decoy tail...
00:19:35
Episode 442
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August 17, 2026
442: When pumps go missing: Ca2+ control of PMCA2 in Tmc1 deafness mutants
Rolseth AB et al., Proceedings of the National Academy of Sciences (PNAS) - This study links reduced Ca2+ entry through mutant TMC1 mechanotransducer channels...
00:22:57
Episode 441
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August 14, 2026
441: Evolutionary mapping of Cav1.3 functional sites
Tang X et al., PNAS - The authors apply an evolutionary sequence-covariation model to the Cav1.3 (CACNA1D) α1-subunit, map predicted pathogenicity onto structural models,...
00:24:01
Episode 440
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August 12, 2026
440: DENV-4: Suppressing DNA Repair and Causing Genome Damage
Lamkina EN et al., PNAS - This episode reviews a PNAS brief report showing that DENV-4 infection induces marked DNA damage in infected cells...
00:23:41
Episode 439
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August 11, 2026
439: Coembedding Sequence and Structure: CLSS Maps the Protein Universe
Longo LM et al., PNAS - This episode summarizes a PNAS study introducing CLSS, a contrastive two-tower protein language model that coembeds domain sequences,...
00:23:08
Episode 438
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August 10, 2026
438: Mapping AIRE: a proactive atlas of 9,790 missense variants
Axakova A et al., The American Journal of Human Genetics - Axakova et al. generated a variant effect map for AIRE using an insulin‑promoter...
00:24:02