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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain

Episode 219

December 05, 2025

219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain

️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-region lipidomics with...

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00:16:41

218: SIM1 and the multi-ancestry genomics of erectile dysfunction

Episode 218

December 04, 2025

218: SIM1 and the multi-ancestry genomics of erectile dysfunction

️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS...

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00:19:37

217: Multiscale triads of meiotic crossover patterning

Episode 217

December 03, 2025

217: Multiscale triads of meiotic crossover patterning

️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2,...

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00:17:47

216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair

Episode 216

December 02, 2025

216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair

️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore This episode...

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00:18:27

215: Protein Set Transformer for high-diversity viromics

Episode 215

December 01, 2025

215: Protein Set Transformer for high-diversity viromics

️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (PST) is...

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00:20:07

214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion

Episode 214

November 30, 2025

214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion

️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an...

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00:18:21