Latest Episodes
Episode 445
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August 22, 2026
445: Why Thymine Survived the UV: Photodamage Pathways Explained
Khosh Abady K et al., PNAS - Spectroscopic comparison of thymine and uracil under 265 nm UVC shows thymine is more photoreactive and absorbs...
00:26:55
Episode 444
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August 19, 2026
444: Many-eyes or Sentinels? How Cost Curvature Shapes Collective Vigilance
Pilgrim C et al., PNAS - A minimal analytical model shows that whether animal groups adopt distributed low-level vigilance (many-eyes) or concentrated high-vigilance roles...
00:24:40
Episode 443
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August 18, 2026
443: 5D‑ASO boosts exon 51 skipping and restores dystrophin in DMD models
Feng P et al., PNAS - This paper describes a bipartite antisense oligonucleotide (5D‑ASO) design that appends a short 5′ splice site decoy tail...
00:19:35
Episode 442
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August 17, 2026
442: When pumps go missing: Ca2+ control of PMCA2 in Tmc1 deafness mutants
Rolseth AB et al., Proceedings of the National Academy of Sciences (PNAS) - This study links reduced Ca2+ entry through mutant TMC1 mechanotransducer channels...
00:22:57
Episode 441
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August 14, 2026
441: Evolutionary mapping of Cav1.3 functional sites
Tang X et al., PNAS - The authors apply an evolutionary sequence-covariation model to the Cav1.3 (CACNA1D) α1-subunit, map predicted pathogenicity onto structural models,...
00:24:01
Episode 440
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August 12, 2026
440: DENV-4: Suppressing DNA Repair and Causing Genome Damage
Lamkina EN et al., PNAS - This episode reviews a PNAS brief report showing that DENV-4 infection induces marked DNA damage in infected cells...
00:23:41