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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

231: Transcription start sites as a germline mutational hotspot

Episode 231

December 17, 2025

231: Transcription start sites as a germline mutational hotspot

️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies a...

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00:17:01

230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome

Episode 230

December 17, 2025

230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome

️Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A recurrent de...

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00:18:27

229: Inhibiting PCBP2 condensates in Alzheimer’s

Episode 229

December 15, 2025

229: Inhibiting PCBP2 condensates in Alzheimer’s

️Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester...

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00:19:55

228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity

Episode 228

December 14, 2025

228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity

️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural and functional...

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00:18:02

227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation

Episode 227

December 13, 2025

227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation

️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This...

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00:16:21

226: FGF4 protects podocytes in diabetic kidney disease

Episode 226

December 12, 2025

226: FGF4 protects podocytes in diabetic kidney disease

️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that...

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00:16:09