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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk

Episode 427

July 23, 2026

427: When Genes Talk to Gut: Microbiome as Mediator of Metabolic Risk

Simpson RC et al., Trends in Genetics - This forum reviews evidence that host genetic variants associated with metabolic disease often overlap with loci...

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00:25:13

426: ProtoCloud — Prototypical self-explaining model for single-cell analysis

Episode 426

July 23, 2026

426: ProtoCloud — Prototypical self-explaining model for single-cell analysis

Guo K et al., Cell Genomics - ProtoCloud is a self-explaining deep generative model that embeds single cells around cell-type-specific prototypes to deliver accurate,...

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00:16:53

425: BEAM: Bayesian reconstruction of metastatic migration histories

Episode 425

July 23, 2026

425: BEAM: Bayesian reconstruction of metastatic migration histories

Staklinski SJ et al., Cell Genomics 6, 101193 (2026) - This episode explores BEAM, a Bayesian framework built on BEAST 2 that jointly infers...

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00:23:31

424: LECA's Ancient Interactome and Modern Disease

Episode 424

July 23, 2026

424: LECA's Ancient Interactome and Modern Disease

Cox RM et al., Cell Genomics 6, 101254 - Cox et al. reconstruct a conserved protein interaction network for the last eukaryotic common ancestor...

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00:12:03

423: How GRN Topology Shapes the Genetic Architecture of Expression

Episode 423

July 22, 2026

423: How GRN Topology Shapes the Genetic Architecture of Expression

Aguirre M et al., Cell Genomics - Aguirre et al. use simulated gene regulatory networks and a linear structural equation model to show how...

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00:25:10

422: Germline rDNA Variants and Human Complex Traits

Episode 422

July 22, 2026

422: Germline rDNA Variants and Human Complex Traits

Rodriguez-Algarra F et al., Cell Genomics - This episode examines a large-scale analysis of germline ribosomal DNA (rDNA) variation in ~500,000 UK Biobank genomes...

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00:20:13