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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

237: Tracing enteric pathogens in Africa with metagenomics and WGS

Episode 237

December 23, 2025

237: Tracing enteric pathogens in Africa with metagenomics and WGS

️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study...

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00:20:00

236: XPD translocation and genetic disease etiology

Episode 236

December 22, 2025

236: XPD translocation and genetic disease etiology

️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals how ATP-driven...

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00:19:54

235: Maternal H3K9 methyltransferases control aRMAE in C. elegans

Episode 235

December 21, 2025

235: Maternal H3K9 methyltransferases control aRMAE in C. elegans

️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color reporters...

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00:17:56

234: MTHFR genotype and methionine metabolism predict COVID-19 severity

Episode 234

December 20, 2025

234: MTHFR genotype and methionine metabolism predict COVID-19 severity

️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC longitudinal metabolomics...

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00:20:27

233: Mechanistic basis of NuA3 recognition and H3K14 acetylation

Episode 233

December 19, 2025

233: Mechanistic basis of NuA3 recognition and H3K14 acetylation

️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures of...

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00:18:48

232: Lamin A/C steers fork restart via H3K9me3 and PARylation

Episode 232

December 18, 2025

232: Lamin A/C steers fork restart via H3K9me3 and PARylation

️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C,...

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00:17:58