Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences

Episode 183

October 30, 2025

183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences

️ Episode 183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences In this episode of PaperCast Base by Base, we...

Play

00:18:05

182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome

Episode 182

October 29, 2025

182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome

️ Episode 182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore a large...

Play

00:16:18

181: Creatine Transporter SLC6A8: Conservation and Variant Impact

Episode 181

October 28, 2025

181: Creatine Transporter SLC6A8: Conservation and Variant Impact

️ Episode 181: Creatine Transporter SLC6A8: Conservation and Variant Impact In this episode of PaperCast Base by Base, we explore how the creatine transporter...

Play

00:12:44

180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction

Episode 180

October 27, 2025

180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction

️ Episode 180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction In this episode of PaperCast Base by Base, we explore how multi-ancestry genome-wide...

Play

00:22:11

179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases

Episode 179

October 26, 2025

179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases

️ Episode 179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases In this episode of PaperCast Base by Base,...

Play

00:16:49

178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications

Episode 178

October 25, 2025

178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications

️ Episode 178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications In this episode of PaperCast Base by Base, we explore how a large...

Play

00:15:59

Previous Next