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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

407: SLC11A2 withholds metals from Salmonella in the gut epithelium

Episode 407

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July 05, 2026

407: SLC11A2 withholds metals from Salmonella in the gut epithelium

Norberg ES et al., Proceedings of the National Academy of Sciences - Using metal‑responsive fluorescent Salmonella reporters, calf intestinal loops, and CRISPR edited epithelial...

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00:21:54

406: Temperature & Age Shape Gut Susceptibility to HCoV-229E

Episode 406

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July 01, 2026

406: Temperature & Age Shape Gut Susceptibility to HCoV-229E

Synowiec A et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study using fetal, pediatric, and adult...

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00:19:53

405: PRDM9 and the Hotspot Trade-off

Episode 405

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July 01, 2026

405: PRDM9 and the Hotspot Trade-off

Úbeda F et al., Proceedings of the National Academy of Sciences (PNAS) - A population-genetic model explains why sequence-specific PRDM9-guided recombination hotspots can evolve...

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00:23:33

404: RUNA Reveals Surface DNA on Exosomes

Episode 404

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June 30, 2026

404: RUNA Reveals Surface DNA on Exosomes

Bošković F et al., Proceedings of the National Academy of Sciences - This study introduces RUNA, a reversible chemistry that selectively labels uridine/thymidine to...

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00:21:02

403: HRD-GIS Evidence for BRCA1/2 Variant Classification

Episode 403

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June 26, 2026

403: HRD-GIS Evidence for BRCA1/2 Variant Classification

Schnaiter et al et al., The American Journal of Human Genetics - Schnaiter et al. pooled Myriad MyChoice HRD+ CDx results from four cohorts...

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00:22:51

402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals

Episode 402

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June 25, 2026

402: When Polygenic Scores Miss: Rare Variants in Misaligned Individuals

Baya N et al., The American Journal of Human Genetics 113, 1–19 (2026) - Baya et al. applied a misalignment framework to UK Biobank...

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00:20:26

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