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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

373: Base by Base 373 — A ciliate rewrites UAA and UAG

Episode 373

May 21, 2026

373: Base by Base 373 — A ciliate rewrites UAA and UAG

McGowan J et al., PLOS Genetics - Genome and transcriptome sequencing of an uncultured Oligohymenophorea ciliate (PL0344) reveals a novel nuclear genetic code in...

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00:21:44

372: Genes, IQ and Socioeconomic Outcomes in Emerging Adults

Episode 372

May 20, 2026

372: Genes, IQ and Socioeconomic Outcomes in Emerging Adults

Kajonius PJ et al., Scientific Reports - This episode examines a twin-study analysis from the German TwinLife panel showing that cognitive ability at age...

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00:24:42

371: Glial epigenomic dysregulation and genetic risk in tauopathies

Episode 371

May 19, 2026

371: Glial epigenomic dysregulation and genetic risk in tauopathies

Han et al., Nature Communications - This study uses paired single-nucleus chromatin accessibility and gene expression profiling across Alzheimer’s disease, Pick’s disease and progressive...

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00:26:06

370: ICMT and INPP5E enable BRAFV600E tumor growth

Episode 370

May 18, 2026

370: ICMT and INPP5E enable BRAFV600E tumor growth

Yang X et al., Proceedings of the National Academy of Sciences - Genetic and pharmacologic inhibition of ICMT suppresses proliferation, invasion, and tumor growth...

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00:23:18

369: NEK2 drives EBV-positive NHL pathogenesis

Episode 369

May 16, 2026

369: NEK2 drives EBV-positive NHL pathogenesis

White MC et al., PNAS - This episode reviews a PNAS study showing that the kinase NEK2 is upregulated by EBV and its latency...

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00:24:30

368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model

Episode 368

May 16, 2026

368: PARP1 and Amyloid: Protecting Neurons in a Familial AD Model

Jhaldiyal A et al., PNAS - This episode summarizes a PNAS study showing that PARP1 activation links Aβ1-42 toxicity to DNA damage, amyloid accumulation,...

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00:26:43

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