Latest Episodes
Episode 289
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February 13, 2026
289: MinION detection of chimeric reads in murine Ifna/Ifnb and Actb amplicons
White R et al., F1000Research - Nanopore MinION sequencing of murine Ifna, Ifnb and Actb amplicons identified post-amplification chimeric reads during library ligation, with...
00:16:18
Episode 288
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February 12, 2026
288: Cryo-EM of rat cerebellar α1/α6 GABAA receptors reveals PZ‑II‑029 binding and β-α-β-α-γ assemblies
Sun C et al., PNAS - Using cryo-EM and mass spectrometry in rat cerebellum, α1- and α6-containing GABAA receptor assemblies (β‑α‑β‑α‑γ stoichiometry) and PZ-II-029...
00:16:55
Episode 287
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February 11, 2026
287: EPOP and MTF2 modulate PRC2 H3K27me3 deposition via GA- and GCN-sequence specificity
Granata J et al., PNAS - In mESCs and defined in vitro assays, EPOP and MTF2 stimulate PRC2 methyltransferase activity and promote de novo...
00:18:47
Episode 286
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February 10, 2026
286: Deep mutational scanning of Nipah virus fusion protein F reveals functional and antigenic constraints
Larsen BB et al., PNAS - Deep mutational scanning of the Nipah virus fusion protein F using pseudoviruses maps ~8,500 single-residue effects, showing F...
00:19:48
Episode 285
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February 09, 2026
285: ESBX (Tb927.3.1660) integrates ESB RNA Pol I localization with BES activation and VSG repression in Trypanosoma brucei
Berazategui MA et al., PNAS - ESBX (Tb927.3.1660) links RNA Pol I localization at the ESB to activation of the active BES and repression...
00:19:39
Episode 284
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February 08, 2026
284: FES, VSMC behavior and pleiotropic vascular genes identified by integrative functional genomics
Solomon CU et al., Nat Commun ( - Integrative analysis in human VSMCs identifies pleiotropic genes including FES that regulate vascular remodeling; pooled CRISPR...
00:17:41