Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

433: Lactate, HSP90α and the Mitochondrial Switch

Episode 433

July 23, 2026

433: Lactate, HSP90α and the Mitochondrial Switch

Wu G et al., Proceedings of the National Academy of Sciences - This episode examines a PNAS study that identifies site-specific lactylation of HSP90α...

Play

00:23:55

432: Echovirus 18: Capsid opening releases the genome

Episode 432

July 23, 2026

432: Echovirus 18: Capsid opening releases the genome

Mukhamedova L et al., Proceedings of the National Academy of Sciences - Using cryo-electron tomography and single-particle cryo-EM of infected Cos-7 cells, the authors...

Play

00:18:29

431: KIAP4 and the ARND family: essential proteins for Leishmania–sand fly adhesion

Episode 431

July 23, 2026

431: KIAP4 and the ARND family: essential proteins for Leishmania–sand fly adhesion

Owino BO et al., Proceedings of the National Academy of Sciences - TurboID proximity labeling and proteomics identify KIAP4 as the canonical member of...

Play

00:21:33

430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes

Episode 430

July 23, 2026

430: Proterozoic Rise: Steady Diversification of Crown Eukaryotes

Sandin MM et al., Proceedings of the National Academy of Sciences - Molecular clocks and diversification models applied to a 75,975-OTU rDNA dataset, including...

Play

00:25:20

429: Validating the EAGL genetic literacy measure

Episode 429

July 23, 2026

429: Validating the EAGL genetic literacy measure

Barna LS et al., Human Genetics and Genomics Advances - We summarize a psychometric validation of the EAGL measure using US adult online samples....

Play

00:23:49

428: Genetic regulation of plasma metabolites in people with HIV

Episode 428

July 23, 2026

428: Genetic regulation of plasma metabolites in people with HIV

Ait Oumelloul M et al., Human Genetics and Genomics Advances - Untargeted plasma metabolomics (1,930 features) in 1,244 participants of the Swiss HIV Cohort...

Play

00:28:03

Next