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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

243: Genome-wide UVB GxE study finds 162 vitamin D variants

Episode 243

December 29, 2025

243: Genome-wide UVB GxE study finds 162 vitamin D variants

️ Episode 243: Genome-wide UVB GxE study finds 162 vitamin D variants In this episode of PaperCast Base by Base, we explore A GWIS...

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00:17:41

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

Episode 242

December 28, 2025

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

️ Episode 242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats In this episode of PaperCast Base by Base, we explore A single intramuscular...

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00:17:40

241: Wagyu T2T reveals a cattle X neocentromere

Episode 241

December 27, 2025

241: Wagyu T2T reveals a cattle X neocentromere

️ Episode 241: Wagyu T2T reveals a cattle X neocentromere In this episode of PaperCast Base by Base, we explore A telomere-to-telomere Wagyu assembly...

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00:18:36

240: CYFIP1 controls cortical axon development by modulating calcium

Episode 240

December 26, 2025

240: CYFIP1 controls cortical axon development by modulating calcium

️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CYFIP1...

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00:18:46

239: Genomic Adaptations of the Svalbard Reindeer

Episode 239

December 25, 2025

239: Genomic Adaptations of the Svalbard Reindeer

️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150...

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00:19:21

238: Germline polymorphisms shape antibody light chain repertoires

Episode 238

December 24, 2025

238: Germline polymorphisms shape antibody light chain repertoires

️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK...

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00:18:14

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