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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

385: Growth under Pressure: Polyploidy Induced by Stress

Episode 385

June 04, 2026

385: Growth under Pressure: Polyploidy Induced by Stress

Sarabia Olivera L et al., PNAS - A perspective that surveys how diverse stresses trigger whole‑genome doubling (polyploidy) across fungi, plants, and animals, outlines...

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00:24:49

384: RNA Brake on Cholera Phage: CisR Controls CTXϕ

Episode 384

June 03, 2026

384: RNA Brake on Cholera Phage: CisR Controls CTXϕ

Haycocks JRJ et al., PNAS - This episode examines the discovery of CisR, a small RNA produced from the 3’UTR of prtV in Vibrio...

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00:23:10

383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links

Episode 383

June 02, 2026

383: Genetics of the Circulating Proteome: pQTLs, Pathways, and Disease Links

Koprulu M et al., Cell - A 38-cohort proteogenomic meta-analysis of up to 78,664 people maps fine‑mapped protein quantitative trait loci (pQTLs) across 1,116...

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00:23:10

382: How animal blood cells evolved from unicellular ancestors

Episode 382

June 02, 2026

382: How animal blood cells evolved from unicellular ancestors

Nagahata Y et al., PNAS - A transcriptome-driven reconstruction of blood cell evolution shows modern animal blood lineages arose by repurposing an ancestral unicellular...

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00:26:12

381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)

Episode 381

June 01, 2026

381: Light-written spatial barcodes enable tunable multiomic sequencing (BALI)

Battistoni G et al., PNAS - This paper presents BALI, a light-driven method that writes combinatorial DNA spatial barcodes directly onto biomolecules in tissue...

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00:26:00

380: Prime-SGE maps drug-resistance variants at scale

Episode 380

May 29, 2026

380: Prime-SGE maps drug-resistance variants at scale

Abadie FMC et al., Cell Genomics - Abadie et al. present prime‑SGE, a pooled prime‑editing framework that installs thousands of precise point mutations across...

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00:11:38

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