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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

Episode 195

November 11, 2025

195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease

️ Episode 195: Tiny Shields: Lymphoid Microglia in Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore how a subset of...

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00:18:22

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

Episode 194

November 10, 2025

194: Bayesian History of Science: Watson and Crick and the Structure of DNA

️ Episode 194: Bayesian History of Science: Watson and Crick and the Structure of DNA In this episode of PaperCast Base by Base, we...

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00:14:29

193: SARM1, DNA, and the Death Signal

Episode 193

November 09, 2025

193: SARM1, DNA, and the Death Signal

️Episode 193: SARM1, DNA, and the Death Signal In this episode of PaperCast Base by Base, we explore how the axon-degenerating enzyme SARM1 acts...

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00:15:00

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

Episode 192

November 08, 2025

192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations

️Episode 192: At Base-Pair Resolution: Chromatin’s Cis-Regulatory Conversations In this episode of PaperCast Base by Base, we explore how base-pair resolution maps of chromatin...

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00:14:24

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

Episode 191

November 07, 2025

191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore...

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00:19:17

190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes

Episode 190

November 06, 2025

190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes

️ Episode 190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes In this episode of PaperCast Base by Base, we explore how...

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00:15:43

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