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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs

Episode 361

May 08, 2026

361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs

Beckner RL et al., PNAS - This episode examines a PNAS study using Chiral Inversion Mutagenesis (ChIM) to scan low-complexity domains (LCDs) of Emerin...

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00:24:38

360: An inverse correlation between structural linguistic and human genetic diversity

Episode 360

May 07, 2026

360: An inverse correlation between structural linguistic and human genetic diversity

Graff A et al., PNAS - A PNAS study linking global population-genetic data and structural linguistic features finds an inverse correlation: regions with lower...

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00:26:51

359: Ultrapotent PDCoV Miniprotein MB11

Episode 359

May 06, 2026

359: Ultrapotent PDCoV Miniprotein MB11

Avery NG et al., PNAS - This episode covers a PNAS study reporting the de novo design of miniprotein inhibitors targeting porcine deltacoronavirus (PDCoV)....

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00:23:06

358: CHCHD4 and a Pediatric OXPHOS Collapse

Episode 358

May 05, 2026

358: CHCHD4 and a Pediatric OXPHOS Collapse

Mantecon M et al., Human Genetics and Genomics Advances - This episode reviews a brief communication reporting a pediatric patient with biallelic CHCHD4 variants...

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00:25:46

356: Recessive Coding Associations Across Six Biobanks

Episode 356

May 03, 2026

356: Recessive Coding Associations Across Six Biobanks

Lassen F et al., The American Journal of Human Genetics - Meta-analysis of up to 948,690 exome- or whole-genome-sequenced individuals across six biobanks used...

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00:22:57

355: Influenza D replicates in the human airway — zoonotic risk

Episode 355

May 03, 2026

355: Influenza D replicates in the human airway — zoonotic risk

Sanders CG et al et al., PNAS - Surveillance-derived influenza D virus (IDV) isolates were tested across cell lines, primary airway cultures, and precision-cut...

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00:24:56