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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

217: Multiscale triads of meiotic crossover patterning

Episode 217

December 03, 2025

217: Multiscale triads of meiotic crossover patterning

️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2,...

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00:17:47

216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair

Episode 216

December 02, 2025

216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair

️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore This episode...

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00:18:27

215: Protein Set Transformer for high-diversity viromics

Episode 215

December 01, 2025

215: Protein Set Transformer for high-diversity viromics

️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (PST) is...

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00:20:07

214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion

Episode 214

November 30, 2025

214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion

️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an...

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00:18:21

213: BRAIN-MAGNET: a functional atlas for non-coding variants

Episode 213

November 29, 2025

213: BRAIN-MAGNET: a functional atlas for non-coding variants

️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples a ChIP-STARR-seq...

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00:20:29

212: Zonal control of mutant β-catenin tumorigenesis

Episode 212

November 28, 2025

212: Zonal control of mutant β-catenin tumorigenesis

️ Episode 212: Zonal control of mutant β-catenin tumorigenesis This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer...

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00:16:47