Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

395: Extended sequence context shapes mutational bias in Escherichia coli

Episode 395

•

June 18, 2026

395: Extended sequence context shapes mutational bias in Escherichia coli

Green R et al., PNAS - Collating >100,000 base-pair substitutions from 32 mutation-accumulation experiments, this study shows that sequence context well beyond adjacent bases...

Play

00:22:43

394: Benchmarking LLMs for cfRNA biomarker discovery

Episode 394

•

June 17, 2026

394: Benchmarking LLMs for cfRNA biomarker discovery

Gaudio HA et al., Nature Communications - This episode examines a systematic benchmark of six commercial large language models applied to plasma cell-free RNA...

Play

00:22:34

393: Hidden Resistance: tNGS Reveals Rifampicin and Bedaquiline Resistance in Eswatini

Episode 393

•

June 17, 2026

393: Hidden Resistance: tNGS Reveals Rifampicin and Bedaquiline Resistance in Eswatini

Vambe D et al., Nature Communications - This study reports the programmatic introduction of targeted next-generation sequencing (tNGS) in Eswatini and shows that tNGS...

Play

00:21:20

392: GWAS of Cocaine Self-Administration in Heterogeneous Stock Rats

Episode 392

•

June 12, 2026

392: GWAS of Cocaine Self-Administration in Heterogeneous Stock Rats

Lara MK et al et al., Nature Communications - Large GWAS in 836 outbred HS rats identifies six loci linked to cocaine self-administration traits,...

Play

00:23:23

391: The Kaufmann Protocol — Why We Age and How to Stop It

Episode 391

•

June 12, 2026

391: The Kaufmann Protocol — Why We Age and How to Stop It

Dr. Sandra Kaufmann, The Kaufmann Anti-Aging Institute - Dr. Sandra Kaufmann — physician, scientist and athlete — set out to understand aging and fight...

Play

01:06:28

390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense

Episode 390

•

June 09, 2026

390: Daunorubicin, Mutual Destruction, and Layered Antiphage Defense

Gätgens C et al., PNAS - This episode examines how DNA-intercalating molecules like daunorubicin block bacteriophage infection at an early stage, causing an abortive-infection-like...

Play

00:22:59