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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

Episode 171

October 18, 2025

171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier?

️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? In this episode of PaperCast Base by Base, we explore a...

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00:16:14

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

Episode 170

October 17, 2025

170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans

️ Episode 170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans In this episode of PaperCast Base by Base, we explore how maternal...

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00:17:03

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

Episode 169

October 16, 2025

169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance

️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance In this episode of PaperCast Base by Base,...

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00:21:13

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

Episode 168

October 15, 2025

168: Low circulating miR-190a-5p predicts progression of chronic kidney disease

️ Episode 168: Low circulating miR-190a-5p predicts progression of chronic kidney disease In this episode of PaperCast Base by Base, we explore how unbiased...

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00:19:10

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

Episode 167

October 14, 2025

167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution

️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution In this episode of PaperCast Base by Base, we explore a Cell...

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00:21:40

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

Episode 166

October 13, 2025

166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments

️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments In this episode of PaperCast Base by Base, we explore...

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00:13:37