Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition

Episode 177

October 24, 2025

177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition

️ Episode 177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition In this episode of PaperCast Base by Base, we explore a multi‑cohort clinical–genomic...

Play

00:17:04

176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma

Episode 176

October 23, 2025

176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma

️ Episode 176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma In this episode of PaperCast Base by Base, we explore how multi-omics integration—spanning...

Play

00:19:32

175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk

Episode 175

October 22, 2025

175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk

️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how enhancer–promoter...

Play

00:19:13

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

Episode 174

October 21, 2025

174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore...

Play

00:16:40

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

Episode 173

October 20, 2025

173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS...

Play

00:20:12

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

Episode 172

October 19, 2025

172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we...

Play

00:19:44