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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

413: Rpc34 WH2 dynamics in RNA polymerase III

Episode 413

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July 12, 2026

413: Rpc34 WH2 dynamics in RNA polymerase III

Wu J-S et al., PNAS - A PNAS study using smFRET and nano-positioning triangulation maps dynamic positioning of the Rpc34 WH2 domain in yeast...

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00:15:24

412: Fault Lines in Forensic Proficiency Testing

Episode 412

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July 12, 2026

412: Fault Lines in Forensic Proficiency Testing

Scurich N et al., PNAS - A concise breakdown of a PNAS perspective that analyzes forensic proficiency testing practices using the 2023 CTS firearms...

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00:28:15

411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity

Episode 411

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July 09, 2026

411: EKV cells and the Human Prion Assay: a scalable platform for sCJD infectivity

Nihata A et al., PNAS - This PNAS study describes the development of EKV, a humanized dividing cell line that propagates bona fide sporadic...

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00:26:33

410: Nucleotide diversity is a poor predictor of short-term adaptive potential

Episode 410

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July 08, 2026

410: Nucleotide diversity is a poor predictor of short-term adaptive potential

Abson KL et al., PNAS - A cross-species synthesis and theory paper showing that simple molecular diversity metrics poorly predict short-term adaptive potential. The...

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00:21:48

409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Episode 409

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July 07, 2026

409: A systems-level atlas of carbon-response transcriptional states in Escherichia coli

Shin J et al., PNAS - This episode examines a large transcriptome compendium (PRECISE-NP881) that profiles E. coli K-12 MG1655 across 43 carbon substrates....

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00:27:15

408: Tau, mitochondria, and the fusion switch

Episode 408

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July 06, 2026

408: Tau, mitochondria, and the fusion switch

Tsakiria E et al., Proceedings of the National Academy of Sciences (PNAS) - Using Tau knockout mice and the C. elegans PTL-1 deletion, this...

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00:24:42

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