Latest Episodes
Episode 366
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May 15, 2026
366: BRCA1P1 suppresses antiviral and antitumor immunity
Han YJ et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study showing that the BRCA1 pseudogene...
00:24:15
Episode 365
•
May 15, 2026
365: MEN1 mutations and menin inhibitor resistance
Bourgeois et al., Nature Communications - This study used enhanced CRISPR base editor screens, structural biology, biochemical assays, and in vitro/in vivo selection to...
00:22:06
Episode 364
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May 11, 2026
364: Peripheral C4 and Schizophrenia: A Neutrophil Gene–Protein Link
Kalinowski A et al., PNAS - This study reports that C4 protein is enriched in human neutrophils and monocytes and that neutrophil C4 protein...
00:17:38
Episode 363
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May 09, 2026
363: cfDNA size deconvolution reveals a 159‑bp nucleosomal pivot and tumor fragmentomic signatures
Zhou Z et al., Nature Communications - This study develops a Lorentzian deconvolution model of cfDNA fragment length distributions across bodily fluids, identifies a...
00:22:29
Episode 362
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May 09, 2026
362: D614G Reshapes Spike Allostery and Speeds RBD Opening
Kearns FL et al., PNAS - Simulations and HDXMS reveal how the D614G substitution alters internal communication in SARS-CoV-2 spike, enabling faster receptor-binding-domain opening...
00:18:48
Episode 361
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May 08, 2026
361: Chiral Inversion Mutagenesis Reveals Structured Hotspots in LCDs
Beckner RL et al., PNAS - This episode examines a PNAS study using Chiral Inversion Mutagenesis (ChIM) to scan low-complexity domains (LCDs) of Emerin...
00:24:38