Latest Episodes
Episode 248
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January 03, 2026
248: Disruption of PIKfyve triggers lysosomal repair and mitochondrial adaptation
Kutchukian C et al., Nature Communications - Disruption of the PIKfyve/Fig4/Vac14 complex drives ULK1-dependent trafficking of PI4KIIα and ATG9A to lysosomes, elevating lysosomal PI(4)P...
00:21:12
Episode 247
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January 02, 2026
247: Genome graphs reveal structural variation in M. tuberculosis
Canalda-Baltrons A et al., Nature Communications - Long-read assemblies and a pangenome reference graph uncover widespread structural variants that shape Mycobacterium tuberculosis evolution and...
00:21:27
Episode 246
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January 01, 2026
246: SV2A structural pharmacology and allosteric occlusion
Pidathala S et al., Nature Communications - High-resolution cryo-EM structures of human SV2A reveal that orthosteric ligands induce an occluded MFS conformation and a...
00:16:44
Episode 245
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December 31, 2025
245: Benchmarking DNA foundation models
Feng H et al., Nat Commun - A comprehensive, unbiased benchmark compares five DNA foundation models across 57 datasets and multiple tasks, finding mean...
00:19:10
Episode 244
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December 30, 2025
244: NEK7 couples SDHB to preserve mitochondrial electron transport and limit liver fibrosis
Sun Z et al., Nature Communications - Mitochondrial NEK7 is imported via MTS peptides, binds SDHB to stabilize complex II conformation, prevent reverse electron...
00:17:38
Episode 243
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December 29, 2025
243: Genome-wide UVB GxE study finds 162 vitamin D variants
Shraim R et al., Nat Commun - A GWIS of 338,977 UK Biobank White British participants using a cumulative weighted ambient UVB measure identified...
00:17:41