Latest Episodes
Episode 272
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January 27, 2026
272: ADSL A429V reduces purine biosynthesis in brain and alters female mouse water-seeking behavior
Ju X-C et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2508540122 - Human-specific ADSL A429V substitution and a common regulatory haplotype reduce ADSL activity and...
00:22:11
Episode 271
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January 25, 2026
271: Rising EA PGI prediction of educational attainment across 1946–1970 British birth cohorts and socioeconomic interaction
Morris TT et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2516460123 - EA and cognition polygenic indexes (PGIs) in three British birth cohorts show EA...
00:19:56
Episode 270
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January 25, 2026
270: Human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes negatively supercoiled DNA measured by optical tweezers
Spakmana D et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2406949123 - Optical tweezers and fluorescence imaging show human Topoisomerase IIIα–RMI1–RMI2 (TRR) processively relaxes highly...
00:22:04
Episode 269
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January 24, 2026
269: Mlh1–Pms1 endonuclease creates single-strand gaps to excise mispairs in S. cerevisiae MMR
Palacio T et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2528670122 - Reconstituted Saccharomyces cerevisiae mismatch repair shows the Mlh1–Pms1 endonuclease directly generates single-strand gaps...
00:20:50
Episode 268
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January 23, 2026
268: M493I in human β-cardiac myosin: SRX disruption, slow ADP release, and enhanced actin attachment
Cail RC et al., Proc. Natl. Acad. Sci. U.S.A. 2025.122:e2521561122 - Recombinant human β-cardiac myosin M493I studied by optical trapping and stopped-flow kinetics disrupts...
00:22:09
Episode 267
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January 22, 2026
267: DNA base-pair opening modes and soliton-like loops revealed by hydrogen exchange
Englander SW et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2520855122 - Hydrogen exchange (H-T and NMR H-H) on DNA and RNA reveals two distinct...
00:21:24