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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

Episode 165

October 12, 2025

165: Protist Genomics: Key to Understanding Eukaryotic Evolution

️ Episode 165: Protist Genomics: Key to Understanding Eukaryotic Evolution In this episode of PaperCast Base by Base, we explore how accelerating protist genomics—spanning...

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00:19:24

164: m6A in the coding sequence: linking deposition, translation, and decay

Episode 164

October 11, 2025

164: m6A in the coding sequence: linking deposition, translation, and decay

️ Episode 164: m6A in the coding sequence: linking deposition, translation, and decay In this episode of PaperCast Base by Base, we explore how...

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00:14:46

163: Animal origins: looping back in time

Episode 1

October 10, 2025

163: Animal origins: looping back in time

️ Episode 163: Animal origins: looping back in time In this episode of PaperCast Base by Base, we explore how chromatin folding mechanisms emerged...

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00:14:18

162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities

Episode 162

October 09, 2025

162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities

️ Episode 162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities In this episode of PaperCast Base by Base, we explore how...

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00:20:15

161: Decoding Genomic Landscapes of Introgression

Episode 161

October 08, 2025

161: Decoding Genomic Landscapes of Introgression

️ Episode 161: Decoding Genomic Landscapes of Introgression In this episode of PaperCast Base by Base, we explore how modern population genetics dissects the...

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00:20:55

160: The Long‑Read Leap in Single‑Cell Omics

October 07, 2025

160: The Long‑Read Leap in Single‑Cell Omics

️ Episode 160: The Long‑Read Leap in Single‑Cell Omics In this episode of PaperCast Base by Base, we explore how long‑read, single‑molecule sequencing has...

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00:15:36