Latest Episodes
Episode 353
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April 30, 2026
353: Masculinization Reverses Sex Differences in Fertility
Schubert HA et al., PNAS - This episode reviews a global analysis showing that shifts in population sex composition have reversed historical sex gaps...
00:27:25
Episode 352
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April 27, 2026
352: Interspecies control of E. coli growth in human gut microbiomes
Boumasmoud M et al., PNAS - Reciprocal transplant experiments in anaerobic microcosms show that resident human gut microbiome context alters growth of introduced Escherichia...
00:25:22
Episode 351
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April 26, 2026
351: When Selection Survives Admixture: Hard Sweeps in Ancient Eurasians
Harris M et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines a PNAS study that uses a domain-adaptive neural...
00:24:52
Episode 350
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April 25, 2026
350: OPA1 A8S in Rhesus Macaques Models Autosomal Dominant Optic Atrophy
Jaggers TN et al et al., PNAS - A spontaneous OPA1 A8S missense mutation in rhesus macaques produces retinal ganglion cell loss, RNFL thinning,...
00:25:26
Episode 349
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April 24, 2026
349: Oxidized rNTPs and Transcription Fidelity: How 8‑oxo‑rGTP Embeds RNA Damage
Hou P et al., PNAS - This study combines kinetic assays and X‑ray crystallography to show how 8‑oxo‑guanosine triphosphate (8‑oxo‑rGTP) is incorporated by RNA...
00:21:13
Episode 348
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April 21, 2026
348: v96: A 96-mutation plasma DNA test to track residual AML through transplant
Wang Y et al et al., PNAS - This episode covers a PNAS study describing v96, a personalized plasma cell-free DNA assay that tracks...
00:23:28