Latest Episodes
Episode 236
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December 22, 2025
236: XPD translocation and genetic disease etiology
Paul T et al., Nat Commun - Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded...
00:19:54
Episode 235
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December 21, 2025
235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
Sands et al., Nature Communications - Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal...
00:17:56
Episode 234
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December 20, 2025
234: MTHFR genotype and methionine metabolism predict COVID-19 severity
Petrova B et al., Proc Natl Acad Sci U S A - IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism...
00:20:32
Episode 233
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December 19, 2025
233: NuA3 structure reveals the mechanism of H3K14 acetylation
Shi W et al., Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex - Cryo-EM structures of the yeast...
00:18:48
Episode 232
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December 18, 2025
232: Lamin A/C steers fork restart via H3K9me3 and PARylation
Cherdyntseva V et al., Nat Commun - Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting...
00:17:58
Episode 231
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December 17, 2025
231: Transcription start sites as a germline mutational hotspot
Cortés Guzmán M et al., Nat Commun - This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in...
00:17:01