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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution

Episode 130

September 07, 2025

130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution

️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this episode of PaperCast...

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00:20:24

129: Structural variation and diversification of the NPIP gene family from the human pangenome

Episode 129

September 06, 2025

129: Structural variation and diversification of the NPIP gene family from the human pangenome

️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base,...

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00:22:11

128: LINE‑1 Promoters Orchestrate Early Human Brain Development

Episode 128

September 05, 2025

128: LINE‑1 Promoters Orchestrate Early Human Brain Development

️ Episode 128: LINE‑1 Promoters Orchestrate Early Human Brain Development In this episode of PaperCast Base by Base, we explore how evolutionarily young LINE‑1...

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00:15:26

127: In silico generation of synthetic cancer genomes using generative AI

Episode 127

September 04, 2025

127: In silico generation of synthetic cancer genomes using generative AI

️ Episode 127: In silico generation of synthetic cancer genomes using generative AI In this episode of PaperCast Base by Base, we explore OncoGAN,...

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00:17:36

126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models

Episode 126

September 03, 2025

126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models

️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of PaperCast Base by Base,...

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00:20:59

125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities

Episode 125

September 02, 2025

125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities

️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episode...

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00:22:46