Latest Episodes
Episode 260
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January 15, 2026
260: TSS hypermutability in human germline linked to RNAP II stalling, R-loops and early embryonic mosaics
Nature Communications - Transcription start sites experience a high influx of heritable variants fueled by early development Music:Enjoy the music based on this article...
00:16:09
Episode 259
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January 14, 2026
259: Ku filaments that hold DNA together
Zahid S et al., Nature Communications, doi:10.1038/s41467-025-65609-y - Cryo-EM and biophysical analyses show Mycobacterium tuberculosis Ku assembles into DNA-bound oligomeric filaments that synapse DNA...
00:17:49
Episode 258
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January 13, 2026
258: Correcting GC bias in metagenomes
Holcik L et al., Nature Communications, doi:10.1038/s41467-025-65530-4 - GuaCAMOLE is an alignment-free algorithm that estimates and removes genomic GC-content-dependent sequencing bias to produce more...
00:17:09
Episode 257
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January 12, 2026
257: PSMC5: proteasomes, immunity and neurodevelopment
Küry S et al., Nature Communications, doi:10.1038/s41467-025-65556-8 - This study describes 26 distinct PSMC5 variants in 44 individuals and demonstrates that PSMC5 loss impairs...
00:18:05
Episode 256
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January 11, 2026
256: Compartmental control of VSG silencing
Antunes et al., Nature Communications - The study shows that spatial segregation of core and subtelomeric chromosome compartments, demarcated by protein-rich boundaries and controlled...
00:18:52
Episode 255
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January 10, 2026
255: Lipids, Ions and the AE1 Elevator
Chen T et al., Nature Communications - Cryo-EM structures, uptake assays, and molecular dynamics show that PIP2 lipids bind at the AE1 dimer interface...
00:19:08