Latest Episodes
Episode 342
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April 14, 2026
342: Modular MPRA Reveals Context-Dependent Regulation at T2D Loci
Tovar A et al., Human Genetics and Genomics Advances - This episode examines a study that used a modular MPRA to test ~11,656 genomic...
00:17:24
Episode 341
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April 13, 2026
341: The Genetic Lottery and the Value of an Extra Year of School
Widding-Havneraas T et al., PNAS - This study uses genetic variation related to educational attainment as a quasi-experimental instrument (Mendelian randomization) together with Norwegian...
00:29:43
Episode 340
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April 12, 2026
340: Microexon Control of Behavior — PTPRD Splicing
Imai A et al., Proceedings of the National Academy of Sciences (PNAS) - This paper shows that alternative splicing of a 12-nt microexon (meB)...
00:17:01
Episode 339
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April 11, 2026
339: cxt: A language model for population genetics
Korfmann K et al., Proceedings of the National Academy of Sciences (PNAS) - This episode examines cxt, a decoder-only transformer that performs next-coalescence prediction...
00:22:39
Episode 338
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April 10, 2026
338: WDHD1 and Microcephalic Primordial Dwarfism
Tibbe D et al., The American Journal of Human Genetics - This study identifies bi-allelic hypomorphic WDHD1 variants in 17 subjects with a clinical...
00:21:40
Episode 337
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April 08, 2026
337: ND-CNVs and internalizing–cardiometabolic multimorbidity
Katzourou IK et al., The American Journal of Human Genetics - Population analysis of ~459,000 UK Biobank participants shows that carriers of neurodevelopmental CNVs...
00:22:39