Latest Episodes
Episode 266
•
January 21, 2026
266: TOP1α and TOP3β Differentially Regulate HPV31 Replication via R-loops and DNA Breaks
Vatsa A et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2526296123 - In HPV31-positive keratinocytes (CIN612), TOP1α and TOP3β are upregulated and required for viral...
00:17:03
Episode 265
•
January 20, 2026
265: ANTSR lncRNA and the conserved multiallelic sex-determining locus across Aculeata
Yu C et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2522417123 - Genetic mapping and comparative genomics show the lncRNA ANTSR multiallelic locus in Aculeata...
00:17:51
Episode 264
•
January 19, 2026
264: Single-TF rejuvenation: EZH2, E2F3, STAT3, ZFX identified by TRDP/Perturb-seq rejuvenate human fibroblasts and mouse liver
Sengstack J et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2515183123 - TRDP with Perturb-seq in human fibroblasts found that manipulating TFs (EZH2, E2F3, STAT3,...
00:19:44
Episode 263
•
January 18, 2026
263: Bifacial γPNA triplets target rCUG repeats and displace MBNL1 in Myotonic Dystrophy type 1
Perera J et al., Proc. Natl. Acad. Sci. U.S.A. 2026.123:e2507065123 - Gamma-PNA triplet ligands with Janus bases selectively bind expanded rCUG repeats, displace MBNL1,...
00:20:24
Episode 262
•
January 17, 2026
262: Human Langerhans cells reprogrammed by tick saliva (CXCR4/CCR7 migration and IDO1/IRF4 tolerance)
Strobl et al., Nature Communications - Human epidermal Langerhans cells exposed to Ixodes ricinus tick saliva and Borrelia burgdorferi adopt a tolerogenic state with...
00:21:40
Episode 261
•
January 16, 2026
261: MHz-XPCS reveals anomalous ferritin diffusion and nanoscale cage trapping
Girelli et al., Nature Communications - MHz-XPCS of ferritin solutions at EuXFEL shows anomalous, cage-trapped protein diffusion with reduced long-time transport and ~1.2 nm...
00:16:20