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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Episode 205

November 21, 2025

205: Ancient RNA Expression Profiles from the Woolly Mammoth

️ Episode 205: Ancient RNA Expression Profiles from the Woolly Mammoth In this episode of PaperCast Base by Base, we explore how ancient RNA...

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00:17:19

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

Episode 204

November 20, 2025

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

️ Episode 204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators In this episode of PaperCast Base by Base, we explore how the StealTHY CRISPR platform...

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00:16:39

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Episode 203

November 19, 2025

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

️ Episode 203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors In this episode of PaperCast Base by Base, we explore how benign and...

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00:18:08

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Episode 202

November 19, 2025

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

️ Episode 202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues In this episode of PaperCast Base by Base, we explore how Stereo-seq...

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00:17:08

201: Sex, Smoking, and Somatic Selection in the Bladder

Episode 201

November 17, 2025

201: Sex, Smoking, and Somatic Selection in the Bladder

️ Episode 201: Sex, Smoking, and Somatic Selection in the Bladder In this episode of PaperCast Base by Base, we explore how ultradeep duplex...

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00:14:52

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Episode 200

November 16, 2025

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

️ Episode 200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline In this episode of PaperCast Base by Base, we explore how...

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00:18:48