Latest Episodes
Episode 238
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December 24, 2025
238: Germline polymorphisms shape antibody light chain repertoires
Engelbrecht E et al., Nat Commun - Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles...
00:18:14
Episode 237
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December 23, 2025
237: Tracing enteric pathogens in Africa with metagenomics and WGS
Thystrup C et al., Nat Commun (2025) - This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of...
00:20:00
Episode 236
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December 22, 2025
236: XPD translocation and genetic disease etiology
Paul T et al., Nat Commun - Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded...
00:19:54
Episode 235
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December 21, 2025
235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
Sands et al., Nature Communications - Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal...
00:17:56
Episode 234
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December 20, 2025
234: MTHFR genotype and methionine metabolism predict COVID-19 severity
Petrova B et al., Proc Natl Acad Sci U S A - IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism...
00:20:32
Episode 233
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December 19, 2025
233: NuA3 structure reveals the mechanism of H3K14 acetylation
Shi W et al., Mechanistic insights into histone recognition and H3K14 acetylation by the NuA3 histone acetyltransferase complex - Cryo-EM structures of the yeast...
00:18:48