Latest Episodes
Episode 296
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February 21, 2026
296: snaR-A ncRNA antagonizes U2 snRNP SF3B2 to drive intron retention in human cells
Zhou S et al., Nature Communications, doi:10.1038/s41467-025-65448-x - snaR-A noncoding RNA interacts with U2 snRNP subunit SF3B2 and nuclear speckles, increasing intron retention and...
00:20:38
Episode 295
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February 19, 2026
295: CFTR deltaF508 and CF-risk variants protect against IBD in large exome study
Yu M et al., Cell Genomics, 6 (2026) 101071. doi:10.1016/j.xgen.2025.101071 - Large-scale exome sequencing shows CFTR risk variants, including deltaF508, reduce susceptibility to inflammatory...
00:28:25
Episode 294
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February 18, 2026
294: Alternative splicing, exonization and lineage-specific isoforms: PTBP1, MAPT and TE-derived exons in mammalian evolution
Hunter CE et al., The EMBO Journal, doi:10.1038/s44318-025-00666-z - Review shows how alternative splicing, via TE exonization and cis-regulatory changes and revealed by long-read...
00:36:58
Episode 293
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February 17, 2026
293: IndeLLM (ESM2) zero-shot scoring and Siamese transfer learning for in-frame indel prediction (MCC 0.77)
Gracia Carmona O et al., Patterns, 7 (2026) 101425. doi:10.1016/j.patter.2025.101425 - IndeLLM uses protein language models (ESM2) to score in-frame indels and a compact...
00:17:53
Episode 292
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February 17, 2026
292: INS R6C signal-peptide defect reduces preproinsulin ER translocation in iPSC-derived βcells
Tong Y et al., EMBO Molecular Medicine, doi:10.1038/s44321-025-00362-9 - Patient data, population genetics and iPSC-derived βcell models show INS R6C impairs preproinsulin ER translocation...
00:17:09
Episode 291
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February 15, 2026
291: Dated gene duplications show Asgard archaeal host complexity before mitochondrial endosymbiosis
Kay CJ et al., Nature, doi:10.1038/s41586-025-09808-z - Relaxed-clock dating of pre-LECA gene duplications in Asgard archaeal and alphaproteobacterial lineages shows a complex archaeal host...
00:06:39