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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

212: Zonal control of mutant β-catenin tumorigenesis

Episode 212

November 28, 2025

212: Zonal control of mutant β-catenin tumorigenesis

Raven A et al. - This study shows that hepatic zonation determines whether mutant β-catenin drives proliferation and liver cancer by forcing differentiation to...

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00:16:47

211: Retention Elements in Cancer Cells

Episode 211

November 27, 2025

211: Retention Elements in Cancer Cells

Sankar et al. - This episode explores the discovery of genetic elements that promote the retention of extrachromosomal DNA (ecDNA) in cancer cells, enhancing...

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00:19:30

210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma

Episode 210

November 26, 2025

210: Tumour-Reactive CD8 T Cell Clusters in Human Melanoma

Tumour-Reactive CD8 T Cell Clusters in Human Melanoma Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09754-w License:This episode...

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00:18:45

209: PERT: Prime Editing tRNAs for Nonsense Mutations

Episode 209

November 25, 2025

209: PERT: Prime Editing tRNAs for Nonsense Mutations

PERT: Prime Editing tRNAs for Nonsense Mutations Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09732-2 License:This episode is...

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00:16:54

208: ZAK, Collided Ribosomes, and the Stress Switch

Episode 208

November 24, 2025

208: ZAK, Collided Ribosomes, and the Stress Switch

ZAK, Collided Ribosomes, and the Stress Switch Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09772-8 License:This episode is...

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00:15:55

207: Semantic Design of de novo Genes with Evo

Episode 207

November 24, 2025

207: Semantic Design of de novo Genes with Evo

Semantic Design of de novo Genes with Evo Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09749-7 License:This episode...

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00:15:05