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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

112: Local Genetic Sex Differences in Quantitative Traits

Episode 112

August 20, 2025

112: Local Genetic Sex Differences in Quantitative Traits

️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences between...

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00:21:16

111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer

Episode 111

August 19, 2025

111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer

️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore...

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00:17:06

110: Whole-exome sequencing identifies new schizophrenia risk genes

Episode 110

August 18, 2025

110: Whole-exome sequencing identifies new schizophrenia risk genes

️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing...

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00:20:31

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

Episode 109

August 17, 2025

109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality

️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA...

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00:18:10

108: Epigenome Editing Reverses HBG Silencing

Episode 108

August 16, 2025

108: Epigenome Editing Reverses HBG Silencing

️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylation...

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00:20:53

107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

Episode 107

August 15, 2025

107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases

Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a...

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00:19:07