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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

206: Wild Birds and the North American H5N1 Epizootic

Episode 206

November 22, 2025

206: Wild Birds and the North American H5N1 Epizootic

Wild Birds and the North American H5N1 Epizootic Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:17:17

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Episode 205

November 21, 2025

205: Ancient RNA Expression Profiles from the Woolly Mammoth

Ancient RNA Expression Profiles from the Woolly Mammoth Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:17:19

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

Episode 204

November 20, 2025

204: StealTHY CRISPR: Revealing Hidden Metastasis Regulators

StealTHY CRISPR: Revealing Hidden Metastasis Regulators Music:Enjoy the music based on this article at the end of the episode. License:CC BY 4.0 International License...

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00:16:39

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Episode 203

November 19, 2025

203: Divergent Evolutionary Dynamics of Benign and Malignant Tumors

Divergent Evolutionary Dynamics of Benign and Malignant Tumors Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:18:14

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Episode 202

November 19, 2025

202: Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues

Stereo-seq V2: Spatial Total RNA Mapping in FFPE Tissues Music:Enjoy the music based on this article at the end of the episode. License:CC BY...

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00:17:08

201: Sex, Smoking, and Somatic Selection in the Bladder

Episode 201

November 17, 2025

201: Sex, Smoking, and Somatic Selection in the Bladder

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09521-x License:This episode is based on an open-access article published under...

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00:14:52