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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

224: Biohybrid implants: wireless sensing with engineered bacteria

Episode 224

December 10, 2025

224: Biohybrid implants: wireless sensing with engineered bacteria

Bilir A et al., Wireless in-body sensing through genetically engineered bacteria - A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals...

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00:18:41

223: Torsion Controls Replication: Stall and Restart

Episode 223

December 09, 2025

223: Torsion Controls Replication: Stall and Restart

Xiaomeng Jia et al., Berger, Smita S - New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and...

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00:16:26

222: snaR-A disrupts mRNA splicing in cancer

Episode 222

December 08, 2025

222: snaR-A disrupts mRNA splicing in cancer

Zhou S et al., Nat Commun - This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear...

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00:17:57

221: Allele-resolved nanopore tour of the human placental methylome

Episode 221

December 07, 2025

221: Allele-resolved nanopore tour of the human placental methylome

Kindlova M et al., Nat Commun - Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and...

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00:20:23

220: AML cell states reveal NPM1 immune-evasion subtypes

Episode 220

December 06, 2025

220: AML cell states reveal NPM1 immune-evasion subtypes

Lilljebjörn H et al., Nat Commun - Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms...

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00:15:48

219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain

Episode 219

December 06, 2025

219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain

Hällqvist J et al., Nature Communications - Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease...

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00:16:41