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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

Episode 242

December 28, 2025

242: AAV9-fcMISv2 gene therapy prevents pregnancy in female cats

Godin P et al., Nature Communications - A single intramuscular injection of an AAV9 vector encoding feline anti‑Müllerian hormone (fcMISv2) in prepubertal kittens produced...

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00:17:40

241: Wagyu T2T reveals a cattle X neocentromere

Episode 241

December 27, 2025

241: Wagyu T2T reveals a cattle X neocentromere

Pineda PS et al., Nature Communications - A telomere-to-telomere Wagyu assembly uncovers a natural neocentromere on the cattle X formed by inverted repeats and...

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00:18:36

240: CYFIP1 controls cortical axon development by modulating calcium

Episode 240

December 26, 2025

240: CYFIP1 controls cortical axon development by modulating calcium

Ricci C et al., Nature Communications - Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function....

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00:18:46

239: Genomic Adaptations of the Svalbard Reindeer

Episode 239

December 25, 2025

239: Genomic Adaptations of the Svalbard Reindeer

Genome Biology and Evolution - The Genomic Basis of the Svalbard Reindeer’s Adaptation to an Extreme Arctic Environment Music:Enjoy the music based on this...

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00:19:21

238: Germline polymorphisms shape antibody light chain repertoires

Episode 238

December 24, 2025

238: Germline polymorphisms shape antibody light chain repertoires

Engelbrecht E et al., Nat Commun - Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles...

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00:18:14

237: Tracing enteric pathogens in Africa with metagenomics and WGS

Episode 237

December 23, 2025

237: Tracing enteric pathogens in Africa with metagenomics and WGS

Thystrup C et al., Nat Commun (2025) - This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of...

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00:20:00