Latest Episodes
Episode 78
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July 17, 2025
78: Unloading Lipids: TTYH2 Meets APOE
Sukalskaia A et al., Nature - This Nature study identifies APOE as an interaction partner of human TTYH2, maps their endosomal colocalization and binding...
00:14:53
Episode 77
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July 16, 2025
77: REX: a range extender for long-distance enhancer activity
Bower G et al., Nature - This paper identifies a conserved cis element, REX, and a [C/T]AATTA homeodomain motif signature that are necessary and...
00:16:31
Episode 76
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July 15, 2025
️ 76: Whole-genome Ancestry of an Old Kingdom Egyptian
️ Episode 76: Whole-genome Ancestry of an Old Kingdom Egyptian In this episode of PaperCast Base by Base, we explore the first 2× coverage...
00:13:22
Episode 75
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July 14, 2025
75: How Metabolism Shapes Enzyme Structures Over 400 Million Years
Lemke O et al., Nature - A deep structural and evolutionary analysis of 11,269 enzyme structures across Saccharomycotina reveals how metabolic context sculpts protein...
00:14:56
Episode 74
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July 13, 2025
74: Benchmarking TCR-epitope predictors with ePytope-TCR
Drost F et al., Cell Genomics - Drost et al. integrated 21 pre-trained sequence-based TCR-epitope predictors into ePytope-TCR and benchmarked them on a viral...
00:20:10
Episode 73
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July 12, 2025
73: Family history and genetics in dementia
König T et al., Genetics in Medicine - A retrospective study of 701 memory clinic patients tested whether stratifying by age at onset and...
00:15:55