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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

Episode 56

June 26, 2025

️ 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis

️ Episode 56: Neuronal Immunoproteasome — A Metabolic Trigger for Ferroptotic Neurodegeneration in Multiple Sclerosis In this episode of Base by Base, we examine...

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00:16:01

55: Jozt�{�kz, JUF and noz�kw mkwm�w��

Episode 55

June 25, 2025

55: Jozt�{�kz, JUF and noz�kw mkwm�w��

Jozt�{�kz yt�{ms{zn~tkw JUF q~{y noz�kw mkwm�w�� et al., Cell - Analysis of Jozt�{�kz in relation to JUF and noz�kw mkwm�w�� across Nk~ltz m~kzt�y contexts,...

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00:14:34

54: Corrupted PDF (unreadable encoding)

Episode 54

June 24, 2025

54: Corrupted PDF (unreadable encoding)

Ioww Moz{ytm� 9 et al., Ioww Moz{ytm� - This episode examines a supplied PDF that appears heavily corrupted/unreadable; we summarize extractable patterns, note limitations,...

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00:18:50

53: Weighing PRS: costs, benefits, and evidence

Episode 53

June 23, 2025

53: Weighing PRS: costs, benefits, and evidence

Siena LM et al., The American Journal of Human Genetics - A systematic review of 24 full economic evaluations assessing polygenic risk score (PRS)–based...

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00:17:13

52: LIZS6 methods and measurements

Episode 52

June 22, 2025

52: LIZS6 methods and measurements

Keener R et al., Cell Genomics - A method-focused excerpt describing LIZS6-related experiments across multiple conditions (NoSk, LSFM) with quantitative readouts and protocol detail....

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00:16:43

51: Finding Hidden mtDNA Diagnoses in Solve-RD

Episode 51

June 21, 2025

51: Finding Hidden mtDNA Diagnoses in Solve-RD

Ratnaike et al et al., The American Journal of Human Genetics - This episode reviews a Solve-RD reanalysis that integrated an mtDNA-focused bioinformatic pipeline...

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00:17:38