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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

201: Sex, Smoking, and Somatic Selection in the Bladder

Episode 201

November 17, 2025

201: Sex, Smoking, and Somatic Selection in the Bladder

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09521-x License:This episode is based on an open-access article published under...

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00:14:52

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Episode 200

November 16, 2025

200: Sperm Sequencing Reveals Extensive Positive Selection in the Male Germline

Music:Enjoy the music based on this article at the end of the episode. DOI:10.1038/s41586-025-09448-3 License:This episode is based on an open-access article published under...

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00:18:48

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

Episode 199

November 15, 2025

199: PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity

PLD4 Deficiency and Lupus: When Nuclease Failure Ignites Autoimmunity Music:Enjoy the music based on this article at the end of the episode. License:This episode...

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00:13:57

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Episode 198

November 14, 2025

198: Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells

Mechanical Confinement and the Shape-Shifting Life of Melanoma Cells Music:Enjoy the music based on this article at the end of the episode. License:This episode...

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00:15:47

197: Somatic Mutation and Selection at Population Scale

Episode 197

November 13, 2025

197: Somatic Mutation and Selection at Population Scale

Somatic Mutation and Selection at Population Scale Music:Enjoy the music based on this article at the end of the episode. License:This episode is based...

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00:15:11

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Episode 196

November 12, 2025

196: Impact of Chromatin Accessibility QTLs Across Immune Contexts

Impact of Chromatin Accessibility QTLs Across Immune Contexts Music:Enjoy the music based on this article at the end of the episode. License:This episode is...

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00:16:37