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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

️30: Heart in the Genes — A New Genetic Syndrome Linked to POPDC2

Episode 30

May 26, 2025

️30: Heart in the Genes — A New Genetic Syndrome Linked to POPDC2

Episode 30: Heart in the Genes — A New Genetic Syndrome Linked to POPDC2 In this episode of Base by Base, we delve into...

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00:26:19

️ 29: Rethinking Agency for Genetic Testing Intention among Latinos — Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing

Episode 29

May 23, 2025

️ 29: Rethinking Agency for Genetic Testing Intention among Latinos — Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing

️ Episode 29: Rethinking Agency for Genetic Testing Intention among Latinos — Determining Predictors of Intention for Carrier Screening and Cancer Predisposition Testing In...

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00:16:18

️ 28: Cell-Type-Resolved TWAS — scPrediXcan Integrates Deep Learning and Single-Cell Data for Transcriptome-Wide Association Studies

Episode 28

May 22, 2025

️ 28: Cell-Type-Resolved TWAS — scPrediXcan Integrates Deep Learning and Single-Cell Data for Transcriptome-Wide Association Studies

️ Episode 28: Cell-Type-Resolved TWAS — scPrediXcan Integrates Deep Learning and Single-Cell Data for Transcriptome-Wide Association Studies In this episode of Base por Base,...

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00:25:04

️ 27: Nucleocytosolic Vehicles — A CRISPR RNP Delivery Breakthrough

Episode 27

May 21, 2025

️ 27: Nucleocytosolic Vehicles — A CRISPR RNP Delivery Breakthrough

️ Episode 27: Nucleocytosolic Vehicles — A CRISPR RNP Delivery Breakthrough In this episode of Base by Base, we delve into a novel virus-like...

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00:16:20

️ 26: Reannotation in Focus — Uncovering Functional Non-Coding Mutations in Melanoma

Episode 26

May 20, 2025

️ 26: Reannotation in Focus — Uncovering Functional Non-Coding Mutations in Melanoma

️ Episode 26: Reannotation in Focus — Uncovering Functional Non-Coding Mutations in Melanoma In this episode of Base por Base, we delve into a...

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00:15:49

️ 25: Uncovering Mitochondrial DNA Diseases — The Solve-RD Experience with Genotype and Phenotype Integration

Episode 25

May 19, 2025

️ 25: Uncovering Mitochondrial DNA Diseases — The Solve-RD Experience with Genotype and Phenotype Integration

️ Episode 25: Uncovering Mitochondrial DNA Diseases — The Solve-RD Experience with Genotype and Phenotype Integration In this episode of Base por Base, we...

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00:16:21