Latest Episodes
Episode 230
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December 17, 2025
230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
Sirvydis K et al., Nat Commun - A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1...
00:18:27
Episode 229
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December 15, 2025
229: Inhibiting PCBP2 condensates in Alzheimer’s
Wang L et al., Nat Commun - Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid...
00:19:55
Episode 228
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December 14, 2025
228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
Gopal AB et al., Nat Commun - Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct...
00:18:02
Episode 227
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December 13, 2025
227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
Couvreu de Deckersberg E et al., Nat Commun (2025) - This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells...
00:16:21
Episode 226
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December 12, 2025
226: FGF4 protects podocytes in diabetic kidney disease
Wang S et al., Nat Commun - This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival...
00:16:09
Episode 225
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December 10, 2025
225: VRK-1, BAF-1 and the release of meiotic chromatin
Paouneskou D et al., Nature Communications - VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans,...
00:17:13