Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

124: Exploring the Omnigenic Architecture of Selected Complex Traits

Episode 124

September 01, 2025

124: Exploring the Omnigenic Architecture of Selected Complex Traits

️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researchers are...

Play

00:23:47

123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease

Episode 123

August 31, 2025

123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease

️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we explore how...

Play

00:18:12

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

Episode 122

August 30, 2025

122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences

️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a study...

Play

00:19:57

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

Episode 121

August 29, 2025

121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma

️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of PaperCast Base by Base,...

Play

00:19:02

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

Episode 120

August 28, 2025

120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment

️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare heterozygous...

Play

00:22:30

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

Episode 119

August 27, 2025

119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells

️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore how stabilizing...

Play

00:18:35