Latest Episodes
Episode 30
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May 26, 2025
30: Bi‑allelic POPDC2 variants and a recessive cardiac conduction syndrome
Nicastro M et al., The American Journal of Human Genetics - Researchers identify bi-allelic POPDC2 variants in multiple families causing sinus-node dysfunction, atrioventricular conduction...
00:26:19
Episode 29
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May 23, 2025
29: Rethinking Agency: Predictors of Genetic Testing Intention among Latinos
Chavez-Yenter D et al., Genetics in Medicine - A cross-sectional SEM study of 503 English-fluent Latino adults applied the Integrated Behavioral Model to identify...
00:16:18
Episode 28
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May 22, 2025
28: scPrediXcan: Deep learning meets single-cell TWAS
Zhou Y et al., Cell Genomics - This paper introduces scPrediXcan, which combines a deep-learning model (ctPred) built on Enformer-derived features with single-cell RNA-seq...
00:25:04
Episode 27
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May 21, 2025
27: ENVLPE+: Shuttling VLPs that load functional CRISPR RNPs
Geilenkeuser J et al., Cell - A Cell paper describing ENVLPE/ENVLPE+, virus-like particles engineered with nucleocytosolic-shuttling Gag-PCP to recruit aptamer-tagged (pe)gRNAs and preferentially package...
00:16:20
Episode 26
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May 20, 2025
26: Reannotation reveals functional non-coding mutations in melanoma
Pepe D et al., The American Journal of Human Genetics (112:1–21, June 5, 2025) - Pepe et al. show that annotating cancer mutations to...
00:15:49
Episode 25
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May 19, 2025
25: mtDNA discovery in Solve‑RD: phenotype‑driven reanalysis
Ratnaike et al et al., The American Journal of Human Genetics - A semi-automated mtDNA reanalysis pipeline using MToolBox and MitoPhen HPO-based phenotype similarity...
00:16:21