Podcast Cover

Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

Hosted by

Latest Episodes

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Episode 48

•

June 16, 2025

48: Mainstreaming Clinical Genetic Testing: A Framework for Care

Mackley MP et al., Genetics in Medicine - A consensus-driven conceptual framework from Canadian genetics experts describing four models for mainstreaming clinical genetic testing...

Play

00:16:11

47: Encoding and decoding chemokine-GPCR selectivity

Episode 47

•

June 16, 2025

47: Encoding and decoding chemokine-GPCR selectivity

Kleist AB et al., Cell - A data-driven mapping of how 46 human chemokines and 23 GPCRs encode selective and promiscuous interactions. The team...

Play

00:22:38

46: How tRNA modifications tune m6A-dependent mRNA decay

Episode 46

•

June 14, 2025

46: How tRNA modifications tune m6A-dependent mRNA decay

Linder B et al., Cell - This episode explores a pan-epitranscriptomic mechanism showing how m6A in coding sequences slows ribosomal decoding to trigger translation-dependent...

Play

00:20:34

45: RNA-dependent mechanics of nucleolar subcompartments

Episode 45

•

June 12, 2025

45: RNA-dependent mechanics of nucleolar subcompartments

Cheng HH et al., Proceedings of the National Academy of Sciences (PNAS) - Using micropipette aspiration in Xenopus laevis oocyte nuclei, authors show the...

Play

00:20:53

44: Polε Proofreading Revealed

Episode 44

•

June 12, 2025

44: Polε Proofreading Revealed

Wang F et al., PNAS - This episode examines a cryo-EM study that captures authentic proofreading intermediates of human Polε in complex with PCNA...

Play

00:19:02

43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping

Episode 43

•

June 11, 2025

43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping

Kjærgaard J et al., Cell - This episode reviews a study that links in vivo insulin sensitivity phenotyping with proteome and signaling-pathway mapping to...

Play

00:19:33