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Base by Base

Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical...more

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Latest Episodes

46: How tRNA modifications tune m6A-dependent mRNA decay

Episode 46

June 14, 2025

46: How tRNA modifications tune m6A-dependent mRNA decay

Linder B et al., Cell - This episode explores a pan-epitranscriptomic mechanism showing how m6A in coding sequences slows ribosomal decoding to trigger translation-dependent...

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00:20:34

45: RNA-dependent mechanics of nucleolar subcompartments

Episode 45

June 12, 2025

45: RNA-dependent mechanics of nucleolar subcompartments

Cheng HH et al., Proceedings of the National Academy of Sciences (PNAS) - Using micropipette aspiration in Xenopus laevis oocyte nuclei, authors show the...

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00:20:53

44: Polε Proofreading Revealed

Episode 44

June 12, 2025

44: Polε Proofreading Revealed

Wang F et al., PNAS - This episode examines a cryo-EM study that captures authentic proofreading intermediates of human Polε in complex with PCNA...

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00:19:02

43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping

Episode 43

June 11, 2025

43: Population heterogeneity, insulin sensitivity, proteome & signaling mapping

Kjærgaard J et al., Cell - This episode reviews a study that links in vivo insulin sensitivity phenotyping with proteome and signaling-pathway mapping to...

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00:19:33

42: Amino acids catalyse RNA formation under ambient alkaline conditions

Episode 42

June 11, 2025

42: Amino acids catalyse RNA formation under ambient alkaline conditions

Rout SK et al., Nature Communications - A Nature Communications study shows that proteinogenic amino acids accelerate non-enzymatic RNA oligomerisation from ribonucleoside-2',3'-cyclic phosphates under...

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00:23:35

41: Valuing Genomic Newborn Screening: Australian Public Preferences

Episode 41

June 10, 2025

41: Valuing Genomic Newborn Screening: Australian Public Preferences

Peters R et al., The American Journal of Human Genetics - This episode reviews a nationwide survey of 2,509 Australian adults using two discrete...

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00:18:43