Latest Episodes
Episode 60
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June 30, 2025
60: Epi-PRS: Genomic LLMs and imputed epigenomics boost polygenic prediction
Zeng W et al., PNAS - This paper introduces Epi-PRS, a workflow that uses genomic large language models to impute cell-type-specific epigenomic features from...
00:17:41
Episode 59
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June 29, 2025
59: Optimizing Engagement in Cancer Genomics
Crossnohere NL et al., Genetics in Medicine - Overview of how the PE-CGS Network defined, implemented, and evaluated strategies to engage participants and communities...
00:22:55
Episode 58
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June 28, 2025
58: Cell competition shapes depletion of aneuploid cells
Fusari E et al., Cell Genomics - Fusari et al. use FLP/FRT–based mosaic methods in Drosophila imaginal epithelia to generate defined segmental monosomies and...
00:22:04
Episode 57
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June 27, 2025
57: Low rates of genetic testing in Medicaid-enrolled children with ASD and ID
Brown TR et al., Genetics in Medicine - This episode reviews a claims-based study of 241,060 Medicaid-enrolled children (ages 7–17) from 2008–2016 that measured...
00:19:40
Episode 56
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June 26, 2025
56: When the Immunoproteasome Turns Toxic: PSMB8, PFKFB3 and Ferroptosis in MS
Woo et al et al., Cell - This study shows that interferon-driven induction of the immunoproteasome subunit PSMB8 in neurons reduces proteasome β5 catalytic...
00:16:01
Episode 55
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June 25, 2025
55: Denisovan DNA from the >146,000-year-old Harbin cranium
Fu Q et al., Cell - Recovery of mitochondrial DNA from dental calculus links the Late Middle Pleistocene Harbin cranium to Denisovans and demonstrates...
00:14:34